C₂₅H₄₈O₂SSi₂

Base Information

• Chemical Name: C₂₅H₄₈O₂SSi₂
• CAS No.: 1422375-09-4
• Molecular Formula: C₂₅H₄₈O₂SSi₂
• Molecular Weight: 468.892
• Mol file: 1422375-09-4.mol

Synonyms:C₂₅H₄₈O₂SSi₂

Chemical Property of C₂₅H₄₈O₂SSi₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₄₈O₂SSi₂

There total 6 articles about C₂₅H₄₈O₂SSi₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C19H34O2SSi (1422375-08-3) + t-butyldimethylsiyl triflate (69739-34-0) → C25H48O2SSi2 (1422375-09-4)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ol400157s

Reference yield:

((2S,3R)-3-(((tert-butyldimethylsilyl)oxy)methyl)oxiran-2-yl)methanol (113123-38-9,134932-33-5,140147-53-1,143615-63-8,140147-52-0) → C25H48O2SSi2 (1422375-09-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: copper(I) bromide dimethylsulfide complex / diethyl ether; tetrahydrofuran / 0.17 h / -50 - -20 °C / Inert atmosphere

1.2: 21 h / -20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: tris(triphenylphosphine)rhodium(l) chloride; hydrogen / benzene; ethanol / 5 h / 20 °C / Inert atmosphere

3.1: pyridine; tributylphosphine / 1 h / 20 °C / Inert atmosphere

4.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With pyridine; 2,6-dimethylpyridine; tris(triphenylphosphine)rhodium(l) chloride; copper(I) bromide dimethylsulfide complex; tributylphosphine; hydrogen; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; benzene;

DOI:10.1021/ol400157s

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → C25H48O2SSi2 (1422375-09-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / -30 °C / Inert atmosphere

2.1: diethyl (2R,3R)-tartrate; titanium(IV)isopropoxide / dichloromethane / 0.33 h / -25 °C / Inert atmosphere

2.2: 63 h / -25 °C / Inert atmosphere

3.1: copper(I) bromide dimethylsulfide complex / diethyl ether; tetrahydrofuran / 0.17 h / -50 - -20 °C / Inert atmosphere

3.2: 21 h / -20 °C / Inert atmosphere

3.3: Inert atmosphere

4.1: tris(triphenylphosphine)rhodium(l) chloride; hydrogen / benzene; ethanol / 5 h / 20 °C / Inert atmosphere

5.1: pyridine; tributylphosphine / 1 h / 20 °C / Inert atmosphere

6.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; tris(triphenylphosphine)rhodium(l) chloride; copper(I) bromide dimethylsulfide complex; diethyl (2R,3R)-tartrate; tributylphosphine; hydrogen; titanium(IV)isopropoxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene; 2.1: |Sharpless Asymmetric Epoxidation;

DOI:10.1021/ol400157s

upstream raw materials:

((2S,3R)-3-(((tert-butyldimethylsilyl)oxy)methyl)oxiran-2-yl)methanol

C₁₉H₃₄O₂SSi

t-butyldimethylsiyl triflate

tert-butyldimethylsilyl chloride

Downstream raw materials:

C₂₅H₄₈O₄SSi₂