ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-[5-(tetrahydropyranyloxy)pentoxy]phenyl}propanoate

Base Information

Chemical Name:ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-[5-(tetrahydropyranyloxy)pentoxy]phenyl}propanoate
CAS No.:197726-32-2
Molecular Formula:C₂₈H₄₄N₂O₇
Molecular Weight:520.667
Hs Code.:

Synonyms:ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-[5-(tetrahydropyranyloxy)pentoxy]phenyl}propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-[5-(tetrahydropyranyloxy)pentoxy]phenyl}propanoate

Chemical Property:

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Technology Process of ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-[5-(tetrahydropyranyloxy)pentoxy]phenyl}propanoate

There total 1 articles about ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-[5-(tetrahydropyranyloxy)pentoxy]phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37935-47-0
2-(5-bromopentyloxy)tetrahydropyran

: 197707-72-5
ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-hydroxyphenyl}propanoate

: 197726-32-2
ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-[5-(tetrahydropyranyloxy)pentoxy]phenyl}propanoate

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF, a) 0 deg C, 10 min, b) 25 deg C, 30 min, 2.) DMF, 75 deg C, 1 h;
DOI:10.1016/S0968-0896(97)00090-4

Reference yield: 43.0%

: 197726-32-2
ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-[5-(tetrahydropyranyloxy)pentoxy]phenyl}propanoate

: 197725-73-8
ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-(5-hydroxypentoxy)phenyl}propanoate

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 45 ℃; for 0.5h;
DOI:10.1016/S0968-0896(97)00090-4

Reference yield:

: 197726-32-2
ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-[5-(tetrahydropyranyloxy)pentoxy]phenyl}propanoate

: 3-[5-(4-Dimethylcarbamoyl-butyrylamino)-2-((E)-7-hydroxy-dodec-5-enyloxy)-phenyl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 43 percent / p-TsOH*H₂O / methanol / 0.5 h / 45 °C

2: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -70 deg C, 30 min, 2.) CH₂Cl₂, 0 deg C, 5 min

3: 1.) NaH / 1.) THF, a) 0 deg C, 10 min, b) 25 deg C, 30 min, 2.) THF, 25 deg C, 1 h

4: NaBH₄ / methanol / 0.25 h / 0 °C

With sodium tetrahydroborate; oxalyl dichloride; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In methanol;
DOI:10.1016/S0968-0896(97)00090-4