ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-(5-hydroxypentoxy)phenyl}propanoate

Base Information

Chemical Name:ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-(5-hydroxypentoxy)phenyl}propanoate
CAS No.:197725-73-8
Molecular Formula:C₂₃H₃₆N₂O₆
Molecular Weight:436.549
Hs Code.:

Synonyms:ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-(5-hydroxypentoxy)phenyl}propanoate

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Chemical Property of ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-(5-hydroxypentoxy)phenyl}propanoate

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Technology Process of ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-(5-hydroxypentoxy)phenyl}propanoate

There total 5 articles about ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-(5-hydroxypentoxy)phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 197726-32-2
ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-[5-(tetrahydropyranyloxy)pentoxy]phenyl}propanoate

: 197725-73-8
ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-(5-hydroxypentoxy)phenyl}propanoate

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 45 ℃; for 0.5h;
DOI:10.1016/S0968-0896(97)00090-4

Reference yield:

: 153136-77-7
(E)-ethyl 3-(2-hydroxy-5-nitrophenyl)acrylate

: 197725-73-8
ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-(5-hydroxypentoxy)phenyl}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 25 °C / 760 Torr

2: 1.) Ph₃P, 2,2'-dipyridyl disulfide / 1.) CH₂Cl₂, 25 deg C, 30 min, 2.) CH₂Cl₂, 25 deg C, 15 min

3: 1.) NaH / 1.) DMF, a) 0 deg C, 10 min, b) 25 deg C, 30 min, 2.) DMF, 75 deg C, 1 h

4: 43 percent / p-TsOH*H₂O / methanol / 0.5 h / 45 °C

With 2,2'-dipyridyldisulphide; hydrogen; sodium hydride; toluene-4-sulfonic acid; triphenylphosphine; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1016/S0968-0896(97)00090-4

Reference yield:

: 37935-47-0
2-(5-bromopentyloxy)tetrahydropyran

: 197725-73-8
ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-(5-hydroxypentoxy)phenyl}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, a) 0 deg C, 10 min, b) 25 deg C, 30 min, 2.) DMF, 75 deg C, 1 h

2: 43 percent / p-TsOH*H₂O / methanol / 0.5 h / 45 °C

With sodium hydride; toluene-4-sulfonic acid; In methanol;
DOI:10.1016/S0968-0896(97)00090-4