(2R,4S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethylhexanamide

Base Information

Chemical Name:(2R,4S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethylhexanamide
CAS No.:192060-47-2
Molecular Formula:C₁₈H₂₉NO₂
Molecular Weight:291.434
Hs Code.:

Synonyms:(2R,4S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethylhexanamide

Suppliers and Price of (2R,4S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethylhexanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethylhexanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethylhexanamide

There total 2 articles about (2R,4S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 29394-58-9
(S)-1-iodo-2-methyl-butane

: 159213-03-3
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide

: 192060-47-2
(2R,4S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethylhexanamide

Guidance literature:: With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; at 23 ℃; for 20h;
DOI:10.1021/ja970402f

Reference yield:

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 192060-47-2
(2R,4S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethylhexanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 0.5 h / 23 °C

2: 94 percent / LiCl, diisopropylamine, n-BuLi / tetrahydrofuran / 20 h / 23 °C

With n-butyllithium; triethylamine; diisopropylamine; lithium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja970402f

Reference yield:

: 192060-47-2
(2R,4S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethylhexanamide

: C₃₄H₄₄O₁₀

Guidance literature:: Multi-step reaction with 13 steps

1.1: n-butyllithium; lithium diisopropyl amide; borane-ammonia complex / hexane; tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.75 h / -78 - 0 °C / Inert atmosphere

3.1: triphenylphosphine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

3.2: 2.75 h / 0 - 20 °C / Inert atmosphere

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 - 20 °C / Inert atmosphere

4.2: 18 h / -78 - 20 °C / Inert atmosphere

5.1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

5.2: 0.17 h / -78 °C / Inert atmosphere

6.1: trimethylamine-N-oxide; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 1.5 h / 70 °C / Inert atmosphere

7.1: copper(l) cyanide / tetrahydrofuran / 0.67 h / -50 - -10 °C / Inert atmosphere

7.2: 0.5 h / -50 - -10 °C / Inert atmosphere

7.3: 2 h / -50 - -10 °C / Inert atmosphere

8.1: Dess-Martin periodane / dichloromethane / 1.5 h / Inert atmosphere

9.1: sodium dihydrogenphosphate; dihydrogen peroxide / water; tert-butyl alcohol / 0.08 h / 0 °C / Inert atmosphere

9.2: 16 h / 0 °C / Inert atmosphere

10.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 2.25 h / 0 - 20 °C / Inert atmosphere

11.1: N-iodo-succinimide; 2,6-dimethylpyridine / 0.03 h / 0 °C / Inert atmosphere

12.1: dichloro bis(acetonitrile) palladium(II); triphenyl-arsane; Tetrabutylammoniumsalz der Diphenylphosphinsaeure / N,N-dimethyl-formamide / 20 h / 20 °C / Darkness; Inert atmosphere; Schlenk technique

12.2: 0.08 h / Inert atmosphere; Darkness; Schlenk technique

12.3: 18 h / Inert atmosphere; Schlenk technique; Darkness

13.1: tris(dimethylamino)sulfonium trimethylsilyldifluoride / N,N-dimethyl-formamide / 16 h / 20 °C / Darkness; Inert atmosphere

With 2,6-dimethylpyridine; dichloro bis(acetonitrile) palladium(II); (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium dihydrogenphosphate; N-iodo-succinimide; n-butyllithium; borane-ammonia complex; oxalyl dichloride; trimethylamine-N-oxide; triphenyl-arsane; tris(dimethylamino)sulfonium trimethylsilyldifluoride; dihydrogen peroxide; copper(l) cyanide; Dess-Martin periodane; dimethyl sulfoxide; triphenylphosphine; Tetrabutylammoniumsalz der Diphenylphosphinsaeure; potassium hydroxide; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 3.1: |Corey-Fuchs Alkyne Synthesis / 4.1: |Corey-Fuchs Alkyne Synthesis / 4.2: |Corey-Fuchs Alkyne Synthesis;
DOI:10.1002/anie.201702189