N-((1R,2S)-3-{ethyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Base Information

Chemical Name:N-((1R,2S)-3-{ethyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea
CAS No.:852661-55-3
Molecular Formula:C₂₄H₃₂FN₇O₂
Molecular Weight:469.562
Hs Code.:

Synonyms:N-((1R,2S)-3-{ethyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Suppliers and Price of N-((1R,2S)-3-{ethyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-((1R,2S)-3-{ethyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-((1R,2S)-3-{ethyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

There total 14 articles about N-((1R,2S)-3-{ethyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852661-54-2
(2S,3R)-3-amino-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

: 382637-78-7
[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-carbamic acid phenyl ester

: 852661-55-3
N-((1R,2S)-3-{ethyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: In acetonitrile; at 25 ℃;

Reference yield:

: 7116-38-3
ethyl 3-(4-fluorophenyl)propanoate

: 852661-55-3
N-((1R,2S)-3-{ethyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide; water / methanol / Heating / reflux

1.2: pH 1

2.1: borane-THF / tetrahydrofuran / 25 °C / Heating / reflux

3.1: pyridine / 168 h / 20 °C

4.1: sodium azide / N,N-dimethyl-formamide / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 2585.81 Torr

6.1: triethylamine / tetrahydrofuran / 0.5 h / 25 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.17 h / 25 °C / Heating / reflux

8.1: ethanol / 25 °C / Heating / reflux

9.1: hydrogen / palladium dihydroxide / methanol; ethyl acetate / 2585.81 Torr

10.1: acetonitrile / 25 °C

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; sodium azide; borane-THF; water; hydrogen; triethylamine; palladium dihydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 136265-10-6,352-03-4,24393-50-8
ethyl 4-fluorocinnamate

: 852661-55-3
N-((1R,2S)-3-{ethyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

2.1: sodium hydroxide; water / methanol / Heating / reflux

2.2: pH 1

3.1: thionyl chloride / dichloromethane / 24 h / 25 °C

4.1: ammonia / tetrahydrofuran; water / 2 h / 0 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

6.1: triethylamine / tetrahydrofuran / 0.5 h / 25 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.17 h / 25 °C / Heating / reflux

8.1: ethanol / 25 °C / Heating / reflux

9.1: hydrogen / palladium dihydroxide / methanol; ethyl acetate / 2585.81 Torr

10.1: acetonitrile / 25 °C

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ammonia; water; hydrogen; triethylamine; palladium dihydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; acetonitrile;