(2S,3R)-3-amino-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

Base Information

Chemical Name:(2S,3R)-3-amino-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol
CAS No.:852661-54-2
Molecular Formula:C₁₅H₂₅FN₂O
Molecular Weight:268.375
Hs Code.:

Synonyms:(2S,3R)-3-amino-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

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Chemical Property of (2S,3R)-3-amino-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

Chemical Property:

Purity/Quality:

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Technology Process of (2S,3R)-3-amino-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

There total 12 articles about (2S,3R)-3-amino-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852661-52-0
(2S,3R)-3-(dibenzylamino)-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

: 852661-54-2
(2S,3R)-3-amino-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

Guidance literature:: With hydrogen; acetic acid; palladium dihydroxide; In methanol;
DOI:10.1016/j.bmcl.2007.11.087

Reference yield:

: 7116-38-3
ethyl 3-(4-fluorophenyl)propanoate

: 852661-54-2
(2S,3R)-3-amino-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide; water / methanol / Heating / reflux

1.2: pH 1

2.1: thionyl chloride / dichloromethane / 24 h / 25 °C

3.1: ammonia / tetrahydrofuran; water / 2 h / 0 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

5.1: triethylamine / tetrahydrofuran / 0.5 h / 25 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.17 h / 25 °C / Heating / reflux

7.1: ethanol / 25 °C / Heating / reflux

8.1: hydrogen / palladium dihydroxide / methanol; ethyl acetate / 2585.81 Torr

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ammonia; water; hydrogen; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 136265-10-6,352-03-4,24393-50-8
ethyl 4-fluorocinnamate

: 852661-54-2
(2S,3R)-3-amino-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

2.1: sodium hydroxide; water / methanol / Heating / reflux

2.2: pH 1

3.1: borane-THF / tetrahydrofuran / 25 °C / Heating / reflux

4.1: pyridine / 168 h / 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 2585.81 Torr

7.1: triethylamine / tetrahydrofuran / 0.5 h / 25 °C

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.17 h / 25 °C / Heating / reflux

9.1: ethanol / 25 °C / Heating / reflux

10.1: hydrogen / palladium dihydroxide / methanol; ethyl acetate / 2585.81 Torr

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; sodium azide; borane-THF; water; hydrogen; triethylamine; palladium dihydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;