(R)-1-[1-(tert-butyldiphenylsiloxy)pentan-3-yl]-4-(4-methoxyphenyl)-1H-tetrazol-5-(4H)-thione

Base Information

Chemical Name:(R)-1-[1-(tert-butyldiphenylsiloxy)pentan-3-yl]-4-(4-methoxyphenyl)-1H-tetrazol-5-(4H)-thione
CAS No.:1260396-21-1
Molecular Formula:C₂₉H₃₆N₄O₂SSi
Molecular Weight:532.782
Hs Code.:

Synonyms:(R)-1-[1-(tert-butyldiphenylsiloxy)pentan-3-yl]-4-(4-methoxyphenyl)-1H-tetrazol-5-(4H)-thione

Suppliers and Price of (R)-1-[1-(tert-butyldiphenylsiloxy)pentan-3-yl]-4-(4-methoxyphenyl)-1H-tetrazol-5-(4H)-thione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-1-[1-(tert-butyldiphenylsiloxy)pentan-3-yl]-4-(4-methoxyphenyl)-1H-tetrazol-5-(4H)-thione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-1-[1-(tert-butyldiphenylsiloxy)pentan-3-yl]-4-(4-methoxyphenyl)-1H-tetrazol-5-(4H)-thione

There total 4 articles about (R)-1-[1-(tert-butyldiphenylsiloxy)pentan-3-yl]-4-(4-methoxyphenyl)-1H-tetrazol-5-(4H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1260396-07-3
(3R)-3-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]pentan-1-ol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1260396-21-1
(R)-1-[1-(tert-butyldiphenylsiloxy)pentan-3-yl]-4-(4-methoxyphenyl)-1H-tetrazol-5-(4H)-thione

Guidance literature:: With 1H-imidazole; dmap; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol102892f

Reference yield:

: C₁₃H₁₆N₄O₂S

: 1260396-21-1
(R)-1-[1-(tert-butyldiphenylsiloxy)pentan-3-yl]-4-(4-methoxyphenyl)-1H-tetrazol-5-(4H)-thione

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol; toluene / 1.5 h / -78 - -30 °C

2: 1H-imidazole; dmap / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; sodium tetrahydroborate; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/ol102892f

Reference yield:

: 13980-76-2
1-(4-methoxyphenyl)-1H-tetrazole-5-thiol

: 1260396-21-1
(R)-1-[1-(tert-butyldiphenylsiloxy)pentan-3-yl]-4-(4-methoxyphenyl)-1H-tetrazol-5-(4H)-thione

Guidance literature:: Multi-step reaction with 3 steps

1.1: (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; benzoic acid / toluene / 0.5 h / -30 °C

1.2: 92 h / -30 °C

2.1: sodium tetrahydroborate / methanol; toluene / 1.5 h / -78 - -30 °C

3.1: 1H-imidazole; dmap / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With 1H-imidazole; (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; dmap; sodium tetrahydroborate; benzoic acid; In tetrahydrofuran; methanol; toluene; 1.1: aza-Michael reaction / 1.2: aza-Michael reaction;
DOI:10.1021/ol102892f