(3R,e)-methyl N-1-(tert-butyldiphenylsilyloxy)pentan-3-yl-N'-(4-methoxyphenyl)carbamimidate

Base Information

Chemical Name:(3R,e)-methyl N-1-(tert-butyldiphenylsilyloxy)pentan-3-yl-N'-(4-methoxyphenyl)carbamimidate
CAS No.:1260510-34-6
Molecular Formula:C₃₀H₄₀N₂O₃Si
Molecular Weight:504.745
Hs Code.:

Synonyms:(3R,e)-methyl N-1-(tert-butyldiphenylsilyloxy)pentan-3-yl-N'-(4-methoxyphenyl)carbamimidate

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Chemical Property of (3R,e)-methyl N-1-(tert-butyldiphenylsilyloxy)pentan-3-yl-N'-(4-methoxyphenyl)carbamimidate

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Technology Process of (3R,e)-methyl N-1-(tert-butyldiphenylsilyloxy)pentan-3-yl-N'-(4-methoxyphenyl)carbamimidate

There total 6 articles about (3R,e)-methyl N-1-(tert-butyldiphenylsilyloxy)pentan-3-yl-N'-(4-methoxyphenyl)carbamimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 67-56-1
methanol

: 1260396-21-1
(R)-1-[1-(tert-butyldiphenylsiloxy)pentan-3-yl]-4-(4-methoxyphenyl)-1H-tetrazol-5-(4H)-thione

: 1260510-34-6
(3R,e)-methyl N-1-(tert-butyldiphenylsilyloxy)pentan-3-yl-N'-(4-methoxyphenyl)carbamimidate

Guidance literature:: With hydrogenchloride; hydrogen; In water; at 20 ℃; for 96h; under 4560.31 Torr;
DOI:10.1021/ol102892f

Reference yield:

: 1260396-07-3
(3R)-3-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]pentan-1-ol

: 1260510-34-6
(3R,e)-methyl N-1-(tert-butyldiphenylsilyloxy)pentan-3-yl-N'-(4-methoxyphenyl)carbamimidate

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole; dmap / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

2: hydrogenchloride; hydrogen / water / 96 h / 20 °C / 4560.31 Torr

With 1H-imidazole; hydrogenchloride; dmap; hydrogen; In tetrahydrofuran; water;
DOI:10.1021/ol102892f

Reference yield:

: 13980-76-2
1-(4-methoxyphenyl)-1H-tetrazole-5-thiol

: 1260510-34-6
(3R,e)-methyl N-1-(tert-butyldiphenylsilyloxy)pentan-3-yl-N'-(4-methoxyphenyl)carbamimidate

Guidance literature:: Multi-step reaction with 4 steps

1.1: (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; benzoic acid / toluene / 0.5 h / -30 °C

1.2: 92 h / -30 °C

2.1: sodium tetrahydroborate / methanol; toluene / 1.5 h / -78 - -30 °C

3.1: 1H-imidazole; dmap / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride; hydrogen / water / 96 h / 20 °C / 4560.31 Torr

With 1H-imidazole; (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; hydrogenchloride; dmap; sodium tetrahydroborate; hydrogen; benzoic acid; In tetrahydrofuran; methanol; water; toluene; 1.1: aza-Michael reaction / 1.2: aza-Michael reaction;
DOI:10.1021/ol102892f