tert-butyl 3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

Base Information

Chemical Name:tert-butyl 3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate
CAS No.:1393900-95-2
Molecular Formula:C₂₉H₃₄F₃N₅O₂
Molecular Weight:541.616
Hs Code.:

Synonyms:tert-butyl 3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

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Chemical Property of tert-butyl 3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

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Technology Process of tert-butyl 3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

There total 10 articles about tert-butyl 3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1393900-87-2
tert-butyl 3-(2-(2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

: 148546-99-0
3-(4-methylpiperazin-1-yl)aniline

: 1393900-95-2
tert-butyl 3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; at 140 - 150 ℃; for 0.5h; microwave irradiation;

Reference yield:

: 618-51-9
3-Iodobenzoic acid

: 1393900-95-2
tert-butyl 3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap / dichloromethane / 64 h / 20 °C / Inert atmosphere

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 0.17 h / Inert atmosphere

2.2: 18 h

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.42 h / 120 °C / microwave irradiation

5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 20 h / 20 °C

6.1: 3-chloro-benzenecarboperoxoic acid / Dichlorofluoromethane / 16 h / 0 - 20 °C

7.1: toluene-4-sulfonic acid / 1,4-dioxane / 0.5 h / 140 - 150 °C / microwave irradiation

With dmap; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; Dichlorofluoromethane; N,N-dimethyl-formamide;

Reference yield:

: 173406-17-2
tert-butyl 3-iodobenzoate

: 1393900-95-2
tert-butyl 3-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 0.17 h / Inert atmosphere

1.2: 18 h

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.42 h / 120 °C / microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 20 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / Dichlorofluoromethane / 16 h / 0 - 20 °C

6.1: toluene-4-sulfonic acid / 1,4-dioxane / 0.5 h / 140 - 150 °C / microwave irradiation

With tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; Dichlorofluoromethane; N,N-dimethyl-formamide;