Technology Process of 1-bromo-4-chloro-2,6-diiodobenzene
There total 1 articles about 1-bromo-4-chloro-2,6-diiodobenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tert.-butylnitrite; copper(ll) bromide;
In
acetonitrile;
at 20 - 50 ℃;
for 12h;
DOI:10.1021/jo1024656
- Guidance literature:
-
2-chloro-4,6-dimethylpyrimidine;
With
n-butyllithium; tri-n-butyl-tin hydride; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 - 0 ℃;
for 4h;
1-bromo-4-chloro-2,6-diiodobenzene;
With
bis(triphenylphosphine)palladium(II) dichloride; lithium chloride;
In
para-xylene;
for 23h;
Reflux;
DOI:10.1021/jo1024656
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium; tri-n-butyl-tin hydride; diisopropylamine / tetrahydrofuran; hexane / 4 h / -78 - 0 °C
1.2: 23 h / Reflux
2.1: tert.-butyl lithium / diethyl ether; pentane / 2 h / -78 °C
2.2: 20 h / -78 °C
With
n-butyllithium; tert.-butyl lithium; tri-n-butyl-tin hydride; diisopropylamine;
In
tetrahydrofuran; diethyl ether; hexane; pentane;
1.2: Stille coupling;
DOI:10.1021/jo1024656
