Technology Process of 1-bromo-4-chloro-2,6-bis(4,6-dimethyl-2-pyrimidinyl)benzene
There total 3 articles about 1-bromo-4-chloro-2,6-bis(4,6-dimethyl-2-pyrimidinyl)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-chloro-4,6-dimethylpyrimidine;
With
n-butyllithium; tri-n-butyl-tin hydride; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 - 0 ℃;
for 4h;
1-bromo-4-chloro-2,6-diiodobenzene;
With
bis(triphenylphosphine)palladium(II) dichloride; lithium chloride;
In
para-xylene;
for 23h;
Reflux;
DOI:10.1021/jo1024656
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 12 h / 20 - 50 °C
2.1: n-butyllithium; tri-n-butyl-tin hydride; diisopropylamine / tetrahydrofuran; hexane / 4 h / -78 - 0 °C
2.2: 23 h / Reflux
With
n-butyllithium; tert.-butylnitrite; tri-n-butyl-tin hydride; diisopropylamine; copper(ll) bromide;
In
tetrahydrofuran; hexane; acetonitrile;
2.2: Stille coupling;
DOI:10.1021/jo1024656
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: iodine; silver sulfate / ethanol / 1 h / 20 °C
2.1: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 12 h / 20 - 50 °C
3.1: n-butyllithium; tri-n-butyl-tin hydride; diisopropylamine / tetrahydrofuran; hexane / 4 h / -78 - 0 °C
3.2: 23 h / Reflux
With
n-butyllithium; tert.-butylnitrite; iodine; tri-n-butyl-tin hydride; silver sulfate; diisopropylamine; copper(ll) bromide;
In
tetrahydrofuran; ethanol; hexane; acetonitrile;
3.2: Stille coupling;
DOI:10.1021/jo1024656
