1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid

Base Information

• Chemical Name: 1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid
• CAS No.: 1188543-36-3
• Molecular Formula: C₁₆H₁₄F₃N₃O₃
• Molecular Weight: 353.301
• Mol file: 1188543-36-3.mol

Synonyms:1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid

Chemical Property of 1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid

There total 2 articles about 1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid ethyl ester (1188543-34-1) → 1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid (1188543-36-3)

Guidance literature:

1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid ethyl ester; With water; sodium hydroxide; In methanol; at 20 - 100 ℃;

With hydrogenchloride; In water;

Reference yield:

methanesulfonic acid 5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl ester (1188542-95-1) → 1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid (1188543-36-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 20 - 80 °C / Inert atmosphere

2: water; sodium hydroxide / methanol / 20 - 100 °C

With water; potassium carbonate; sodium hydroxide; In methanol; acetone;

Reference yield: 88.0%

1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid (1188543-36-3) + 5,6-diamino-3-propyluracil (142665-13-2) → 1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid (6-amino-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide (1188543-37-4)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; at 20 ℃; Inert atmosphere;

upstream raw materials:

1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid ethyl ester

methanesulfonic acid 5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl ester

Downstream raw materials:

1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid (6-amino-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

3-(2-amino-ethyl)-8-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydro-purine-2,6-dione

3-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-8-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydro-purine-2,6-dione

1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid {6-amino-1-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl}-amide