3-(2-amino-ethyl)-8-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydro-purine-2,6-dione

Base Information

Chemical Name:3-(2-amino-ethyl)-8-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydro-purine-2,6-dione
CAS No.:1188543-33-0
Molecular Formula:C₂₅H₂₇F₃N₈O₃
Molecular Weight:544.536
Hs Code.:

Synonyms:3-(2-amino-ethyl)-8-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydro-purine-2,6-dione

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Chemical Property of 3-(2-amino-ethyl)-8-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydro-purine-2,6-dione

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Technology Process of 3-(2-amino-ethyl)-8-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydro-purine-2,6-dione

There total 7 articles about 3-(2-amino-ethyl)-8-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydro-purine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1188543-39-6
3-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-8-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydro-purine-2,6-dione

: 1188543-33-0
3-(2-amino-ethyl)-8-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydro-purine-2,6-dione

Guidance literature:: With hydrazine; In ethanol; at 20 ℃; for 1h;

Reference yield:

: 1188543-34-1
1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid ethyl ester

: 1188543-33-0
3-(2-amino-ethyl)-8-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydro-purine-2,6-dione

Guidance literature:: Multi-step reaction with 5 steps

1: water; sodium hydroxide / methanol / 20 - 100 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / methanol / 20 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4: phosphorus pentoxide / N,N-dimethyl-formamide / 0.08 h / 100 °C / Inert atmosphere

5: hydrazine / ethanol / 1 h / 20 °C

With phosphorus pentoxide; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; hydrazine; In methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1188543-37-4
1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid (6-amino-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

: 1188543-33-0
3-(2-amino-ethyl)-8-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydro-purine-2,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: phosphorus pentoxide / N,N-dimethyl-formamide / 0.08 h / 100 °C / Inert atmosphere

3: hydrazine / ethanol / 1 h / 20 °C

With phosphorus pentoxide; potassium carbonate; hydrazine; In ethanol; N,N-dimethyl-formamide;