2-hydroxy-1,3-dioxo-N-(4-(prop-2-ynyloxy)phenethyl)isoindoline-5-carboxamide

Base Information

Chemical Name:2-hydroxy-1,3-dioxo-N-(4-(prop-2-ynyloxy)phenethyl)isoindoline-5-carboxamide
CAS No.:863990-95-8
Molecular Formula:C₂₀H₁₆N₂O₅
Molecular Weight:364.357
Hs Code.:

Synonyms:2-hydroxy-1,3-dioxo-N-(4-(prop-2-ynyloxy)phenethyl)isoindoline-5-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-hydroxy-1,3-dioxo-N-(4-(prop-2-ynyloxy)phenethyl)isoindoline-5-carboxamide

Chemical Property:

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Technology Process of 2-hydroxy-1,3-dioxo-N-(4-(prop-2-ynyloxy)phenethyl)isoindoline-5-carboxamide

There total 3 articles about 2-hydroxy-1,3-dioxo-N-(4-(prop-2-ynyloxy)phenethyl)isoindoline-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 863990-94-7
2-(4-methoxybenzyloxy)-1,3-dioxo-N-(4-(prop-2-ynyloxy)phenethyl)isoindoline-5-carboxamide

: 863990-95-8
2-hydroxy-1,3-dioxo-N-(4-(prop-2-ynyloxy)phenethyl)isoindoline-5-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jo050722e

Reference yield:

: 863990-91-4
2-(4-methoxybenzyloxy)-1,3-dioxoisoindoline-5-carboxylic acid

: 863990-95-8
2-hydroxy-1,3-dioxo-N-(4-(prop-2-ynyloxy)phenethyl)isoindoline-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / PyBOP; DIPEA / CH₂Cl₂ / 24 h / 20 °C

2: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo050722e

Reference yield:

: 552-30-7,145253-53-8
trimellitic Anhydride

: 863990-95-8
2-hydroxy-1,3-dioxo-N-(4-(prop-2-ynyloxy)phenethyl)isoindoline-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / pyridine / 24 h / 90 °C

2: 93 percent / PyBOP; DIPEA / CH₂Cl₂ / 24 h / 20 °C

3: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo050722e