3-(4-methoxybenzyl)-7-phenyl-4-tosyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one

Base Information

• Chemical Name: 3-(4-methoxybenzyl)-7-phenyl-4-tosyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one
• CAS No.: 1202754-29-7
• Molecular Formula: C₃₀H₂₇NO₅S
• Molecular Weight: 513.614
• Mol file: 1202754-29-7.mol

Synonyms:3-(4-methoxybenzyl)-7-phenyl-4-tosyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one

Chemical Property of 3-(4-methoxybenzyl)-7-phenyl-4-tosyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methoxybenzyl)-7-phenyl-4-tosyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one

There total 2 articles about 3-(4-methoxybenzyl)-7-phenyl-4-tosyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

carbon monoxide (201230-82-2) + N-(p-toluenesulfonyl)-2-(4-methoxybenzyl)aziridine (442158-18-1) + 2-iodo-4-phenylphenol (71031-48-6) → 3-(4-methoxybenzyl)-7-phenyl-4-tosyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (1202754-29-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; at 80 ℃; for 24h; under 10343.2 Torr; regioselective reaction; Autoclave;

DOI:10.1021/ol902598d

Reference yield: 56.0%

carbon monoxide (201230-82-2) + N-(p-toluenesulfonyl)-2-(4-methoxybenzyl)aziridine (442158-18-1) + 2-bromo-4-phenylphenol (92-03-5) → 3-(4-methoxybenzyl)-7-phenyl-4-tosyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (1202754-29-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis(diphenylphosphino)ferrocene; 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 48h; under 20686.5 Torr; regioselective reaction; Autoclave;

DOI:10.1021/ol902598d

upstream raw materials:

carbon monoxide

N-(p-toluenesulfonyl)-2-(4-methoxybenzyl)aziridine

2-bromo-4-phenylphenol

2-iodo-4-phenylphenol