(4-(1,1-difluoroprop-1-en-2-yl)phenyl)(methyl)sulfane

Base Information

• Chemical Name: (4-(1,1-difluoroprop-1-en-2-yl)phenyl)(methyl)sulfane
• CAS No.: 1620096-74-3
• Molecular Formula: C₁₀H₁₀F₂S
• Molecular Weight: 200.252
• Mol file: 1620096-74-3.mol

Synonyms:(4-(1,1-difluoroprop-1-en-2-yl)phenyl)(methyl)sulfane

Chemical Property of (4-(1,1-difluoroprop-1-en-2-yl)phenyl)(methyl)sulfane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(1,1-difluoroprop-1-en-2-yl)phenyl)(methyl)sulfane

There total 2 articles about (4-(1,1-difluoroprop-1-en-2-yl)phenyl)(methyl)sulfane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl(4-(3,3,3-trifluoroprop-1-en-2-yl)phenyl)sulfane → (4-(1,1-difluoroprop-1-en-2-yl)phenyl)(methyl)sulfane (1620096-74-3)

Guidance literature:

With phenylsilane; C₂₆H₂₇N₃NiO₂; In benzene-d6; at 20 ℃; for 24h; chemoselective reaction; Inert atmosphere; Glovebox;

DOI:10.1021/jacs.9b13757

Reference yield:

4-(Methylthio)acetophenone (1778-09-2) + [tris(dimethylamino)phosphonio]difluoroacetate (1449521-17-8) → (4-(1,1-difluoroprop-1-en-2-yl)phenyl)(methyl)sulfane (1620096-74-3)

Guidance literature:

In N,N-dimethyl acetamide; toluene; at 100 ℃; for 3h; Sealed tube; Inert atmosphere; Glovebox;

DOI:10.1021/jo501289v

Reference yield:

(4-(1,1-difluoroprop-1-en-2-yl)phenyl)(methyl)sulfane (1620096-74-3) → methyl(4-(1,1,1-trifluoropropan-2-yl)phenyl)sulfane (1620096-31-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 100 ℃; for 30h; Inert atmosphere; Sealed tube;

DOI:10.1021/jo501289v

upstream raw materials:

4-(Methylthio)acetophenone

[tris(dimethylamino)phosphonio]difluoroacetate

Downstream raw materials:

methyl(4-(1,1,1-trifluoropropan-2-yl)phenyl)sulfane