methyl (S)-2-tert-butoxycarbonyl-7-(2-{2-[(E)-2-cyclohexylvinyl]-5-methyloxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Base Information

Chemical Name:methyl (S)-2-tert-butoxycarbonyl-7-(2-{2-[(E)-2-cyclohexylvinyl]-5-methyloxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
CAS No.:1355450-42-8
Molecular Formula:C₃₀H₄₀N₂O₆
Molecular Weight:524.657
Hs Code.:

Synonyms:methyl (S)-2-tert-butoxycarbonyl-7-(2-{2-[(E)-2-cyclohexylvinyl]-5-methyloxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

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Chemical Property of methyl (S)-2-tert-butoxycarbonyl-7-(2-{2-[(E)-2-cyclohexylvinyl]-5-methyloxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

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Technology Process of methyl (S)-2-tert-butoxycarbonyl-7-(2-{2-[(E)-2-cyclohexylvinyl]-5-methyloxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

There total 6 articles about methyl (S)-2-tert-butoxycarbonyl-7-(2-{2-[(E)-2-cyclohexylvinyl]-5-methyloxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 477533-85-0
2-{2-[(E)-2-cyclohexylvinyl]-5-methyloxazol-4-yl}ethyl methanesulfonate

: 262616-16-0
methyl (S)-2-tert-butoxycarbonyl-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

: 1355450-42-8
methyl (S)-2-tert-butoxycarbonyl-7-(2-{2-[(E)-2-cyclohexylvinyl]-5-methyloxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Guidance literature:: With tetraethylammonium fluoride; potassium carbonate; In toluene; at 90 ℃; for 12h;
DOI:10.1248/cpb.59.1233

Reference yield:

: 56453-86-2
(E)-3-cyclohexylprop-2-enoic acid

: 1355450-42-8
methyl (S)-2-tert-butoxycarbonyl-7-(2-{2-[(E)-2-cyclohexylvinyl]-5-methyloxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; isobutyl chloroformate / dichloromethane / 0.33 h / 10 °C

1.2: 1 h / 10 °C

2.1: 4-methyl-morpholine; dmap; acetic anhydride / toluene / 1.5 h / 60 - 70 °C

3.1: trichlorophosphate / toluene / 0.75 h / 100 °C

4.1: diisobutylaluminium hydride / toluene / 1 h / -40 °C

5.1: triethylamine / dichloromethane / 0.33 h / 0 °C

6.1: tetraethylammonium fluoride; potassium carbonate / toluene / 12 h / 90 °C

With 4-methyl-morpholine; dmap; acetic anhydride; diisobutylaluminium hydride; tetraethylammonium fluoride; potassium carbonate; triethylamine; trichlorophosphate; isobutyl chloroformate; In dichloromethane; toluene; 2.1: Dakin-West reaction;
DOI:10.1248/cpb.59.1233

Reference yield:

: C₁₄H₂₁NO₅

: 1355450-42-8
methyl (S)-2-tert-butoxycarbonyl-7-(2-{2-[(E)-2-cyclohexylvinyl]-5-methyloxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methyl-morpholine; dmap; acetic anhydride / toluene / 1.5 h / 60 - 70 °C

2: trichlorophosphate / toluene / 0.75 h / 100 °C

3: diisobutylaluminium hydride / toluene / 1 h / -40 °C

4: triethylamine / dichloromethane / 0.33 h / 0 °C

5: tetraethylammonium fluoride; potassium carbonate / toluene / 12 h / 90 °C

With 4-methyl-morpholine; dmap; acetic anhydride; diisobutylaluminium hydride; tetraethylammonium fluoride; potassium carbonate; triethylamine; trichlorophosphate; In dichloromethane; toluene; 1: Dakin-West reaction;
DOI:10.1248/cpb.59.1233