Technology Process of 2-{2-[(E)-2-cyclohexylvinyl]-5-methyloxazol-4-yl}ethyl methanesulfonate
There total 5 articles about 2-{2-[(E)-2-cyclohexylvinyl]-5-methyloxazol-4-yl}ethyl methanesulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; isobutyl chloroformate / dichloromethane / 0.33 h / 10 °C
1.2: 1 h / 10 °C
2.1: 4-methyl-morpholine; dmap; acetic anhydride / toluene / 1.5 h / 60 - 70 °C
3.1: trichlorophosphate / toluene / 0.75 h / 100 °C
4.1: diisobutylaluminium hydride / toluene / 1 h / -40 °C
5.1: triethylamine / dichloromethane / 0.33 h / 0 °C
With
4-methyl-morpholine; dmap; acetic anhydride; diisobutylaluminium hydride; triethylamine; trichlorophosphate; isobutyl chloroformate;
In
dichloromethane; toluene;
2.1: Dakin-West reaction;
DOI:10.1248/cpb.59.1233
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 4-methyl-morpholine; dmap; acetic anhydride / toluene / 1.5 h / 60 - 70 °C
2: trichlorophosphate / toluene / 0.75 h / 100 °C
3: diisobutylaluminium hydride / toluene / 1 h / -40 °C
4: triethylamine / dichloromethane / 0.33 h / 0 °C
With
4-methyl-morpholine; dmap; acetic anhydride; diisobutylaluminium hydride; triethylamine; trichlorophosphate;
In
dichloromethane; toluene;
1: Dakin-West reaction;
DOI:10.1248/cpb.59.1233
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trichlorophosphate / toluene / 0.75 h / 100 °C
2: diisobutylaluminium hydride / toluene / 1 h / -40 °C
3: triethylamine / dichloromethane / 0.33 h / 0 °C
With
diisobutylaluminium hydride; triethylamine; trichlorophosphate;
In
dichloromethane; toluene;
DOI:10.1248/cpb.59.1233
