(7S,8S,9R)-8-Cyano-7,9-diphenyl-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid amide

Base Information

Chemical Name:(7S,8S,9R)-8-Cyano-7,9-diphenyl-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid amide
CAS No.:210306-61-9
Molecular Formula:C₂₂H₂₂N₂O₃
Molecular Weight:362.428
Hs Code.:

Synonyms:(7S,8S,9R)-8-Cyano-7,9-diphenyl-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid amide

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Chemical Property of (7S,8S,9R)-8-Cyano-7,9-diphenyl-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid amide

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Technology Process of (7S,8S,9R)-8-Cyano-7,9-diphenyl-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid amide

There total 1 articles about (7S,8S,9R)-8-Cyano-7,9-diphenyl-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 107-21-1
ethylene glycol

: (2S,6R)-1-Cyano-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid amide

: 210306-61-9
(7S,8S,9R)-8-Cyano-7,9-diphenyl-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid amide

Guidance literature:: With TSA; In benzene; for 5.2h; Heating;
DOI:10.1021/jo9801059

Reference yield: 80.0%

: 210306-61-9
(7S,8S,9R)-8-Cyano-7,9-diphenyl-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid amide

: 210306-53-9
(7S,8R,9R)-7,9-Diphenyl-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid amide

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; at 150 ℃; for 5h;
DOI:10.1021/jo9801059

Reference yield:

: 210306-61-9
(7S,8S,9R)-8-Cyano-7,9-diphenyl-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid amide

: 2(e),6(e)-diphenyl-4-oxocyclohexane-1(e)-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / aq. KOH / dimethylsulfoxide / 5 h / 150 °C

2: 86 percent / conc. HCl / acetone / 1 h / Heating

With hydrogenchloride; potassium hydroxide; In dimethyl sulfoxide; acetone;
DOI:10.1021/jo9801059