N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-((dimethylamino)methyl)-2-fluoroaniline

Base Information

Chemical Name:N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-((dimethylamino)methyl)-2-fluoroaniline
CAS No.:1352609-61-0
Molecular Formula:C₂₅H₂₅FN₈
Molecular Weight:456.526
Hs Code.:

Synonyms:N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-((dimethylamino)methyl)-2-fluoroaniline

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Chemical Property of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-((dimethylamino)methyl)-2-fluoroaniline

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Technology Process of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-((dimethylamino)methyl)-2-fluoroaniline

There total 9 articles about N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-((dimethylamino)methyl)-2-fluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₃FN₈

: 1352609-61-0
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-((dimethylamino)methyl)-2-fluoroaniline

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; methanol; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 946125-65-1
1-(bromomethyl)-2-fluoro-3- nitrobenzene

: 1352609-61-0
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-((dimethylamino)methyl)-2-fluoroaniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride; iron / ethanol / 2 h / Reflux

3.1: acetic acid / 1,2-dichloro-ethane / 2 h / 120 °C / Inert atmosphere; Sealed tube

4.1: sodium tris(acetoxy)borohydride / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tris(acetoxy)borohydride; iron; acetic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 1352609-95-0
1-(2-fluoro-3-nitrophenyl)-N,N-dimethylmethanamine

: 1352609-61-0
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-((dimethylamino)methyl)-2-fluoroaniline

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; iron / ethanol / 2 h / Reflux

2: acetic acid / 1,2-dichloro-ethane / 2 h / 120 °C / Inert atmosphere; Sealed tube

3: sodium tris(acetoxy)borohydride / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tris(acetoxy)borohydride; iron; acetic acid; In tetrahydrofuran; methanol; ethanol; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.03.022