diethyl 4-[2-(benzylamino)-1,1-difluoro-2-oxoethyl]-1,4-cyclohexadiene-1,2-dicarboxylate

Base Information

Chemical Name:diethyl 4-[2-(benzylamino)-1,1-difluoro-2-oxoethyl]-1,4-cyclohexadiene-1,2-dicarboxylate
CAS No.:1403621-41-9
Molecular Formula:C₂₁H₂₃F₂NO₅
Molecular Weight:407.414
Hs Code.:

Synonyms:diethyl 4-[2-(benzylamino)-1,1-difluoro-2-oxoethyl]-1,4-cyclohexadiene-1,2-dicarboxylate

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Chemical Property of diethyl 4-[2-(benzylamino)-1,1-difluoro-2-oxoethyl]-1,4-cyclohexadiene-1,2-dicarboxylate

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Technology Process of diethyl 4-[2-(benzylamino)-1,1-difluoro-2-oxoethyl]-1,4-cyclohexadiene-1,2-dicarboxylate

There total 3 articles about diethyl 4-[2-(benzylamino)-1,1-difluoro-2-oxoethyl]-1,4-cyclohexadiene-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 957109-35-2
N-benzyl-2,2-difluoro-3-butynamide

: 3710-30-3
1,7-Octadiene

: 762-21-0
acetylenedicarboxylic acid diethyl ester

: 1403621-41-9
diethyl 4-[2-(benzylamino)-1,1-difluoro-2-oxoethyl]-1,4-cyclohexadiene-1,2-dicarboxylate

Guidance literature:: With [2-(i-PrO)-C₆H₄]C(H)=RuCH[(Mes)NCH₂CH₂N(Mes)]Cl₂; In toluene; at 90 ℃; for 6h; Sealed tube; Inert atmosphere;
DOI:10.1002/chem.201200835

Reference yield:

: 1609462-76-1
N-benzyl-2,2-difluoro-3-methylenepent-4-enamide

: 762-21-0
acetylenedicarboxylic acid diethyl ester

: 1403621-41-9
diethyl 4-[2-(benzylamino)-1,1-difluoro-2-oxoethyl]-1,4-cyclohexadiene-1,2-dicarboxylate

Guidance literature:: In toluene; at 90 ℃; for 6h; Sealed tube; Inert atmosphere;
DOI:10.3762/bjoc.9.305

Reference yield:

: 957109-35-2
N-benzyl-2,2-difluoro-3-butynamide

: 1403621-41-9
diethyl 4-[2-(benzylamino)-1,1-difluoro-2-oxoethyl]-1,4-cyclohexadiene-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 2 h / 90 °C / 760.05 Torr / Sealed tube

2: toluene / 6 h / 90 °C / Sealed tube; Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In toluene; 2: |Diels-Alder Cycloaddition;
DOI:10.3762/bjoc.9.305