(S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(3-methylisoxazol-5-yl)ethanamine

Base Information

Chemical Name:(S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(3-methylisoxazol-5-yl)ethanamine
CAS No.:1365530-26-2
Molecular Formula:C₁₈H₁₄ClF₄N₃O
Molecular Weight:399.775
Hs Code.:

Synonyms:(S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(3-methylisoxazol-5-yl)ethanamine

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Chemical Property of (S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(3-methylisoxazol-5-yl)ethanamine

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Technology Process of (S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(3-methylisoxazol-5-yl)ethanamine

There total 6 articles about (S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(3-methylisoxazol-5-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89809-64-3
2-cyano-5-chloropyridine

: 1365530-26-2
(S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(3-methylisoxazol-5-yl)ethanamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / diethyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 14 h / 75 °C

3.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h

4.2: pH 10

With hydrogenchloride; titanium(IV) tetraethanolate; n-butyllithium; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether;
DOI:10.1016/j.tet.2012.01.050

Reference yield:

: (S)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(3-methylisoxazol-5-yl)ethyl)-2-methylpropane-2-sulfinamide

: 1365530-26-2
(S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(3-methylisoxazol-5-yl)ethanamine

Guidance literature:: (S)-N-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(3-methylisoxazol-5-yl)ethyl)-2-methylpropane-2-sulfinamide; With hydrogenchloride; methanol; In 1,4-dioxane; at 20 ℃; for 0.5h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 939425-86-2
C₂₂H₂₂ClF₄N₃O₂S

: 1365530-26-2
(S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(3-methylisoxazol-5-yl)ethanamine

Guidance literature:: C₂₂H₂₂ClF₄N₃O₂S; With hydrogenchloride; In 1,4-dioxane; methanol; for 0.5h;

With sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; pH=10;
DOI:10.1016/j.tet.2012.01.050