89809-64-3 Usage
Description
5-Chloro-2-cyanopyridine is a light yellow crystalline compound with the chemical formula C6H3ClN2. It is an organic synthesis intermediate and possesses a chloro and a cyano group attached to a pyridine ring, which endows it with unique chemical properties and reactivity.
Uses
Used in Organic Synthesis:
5-Chloro-2-cyanopyridine is used as a key intermediate in the synthesis of various organic compounds. Its presence of both a chloro and a cyano group allows for versatile chemical reactions, such as nucleophilic substitution, addition, and cyclization, making it a valuable building block for the development of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Chloro-2-cyanopyridine is used as a starting material for the synthesis of various drug candidates. Its unique structure and reactivity enable the creation of novel compounds with potential therapeutic applications, such as antimicrobial, antiviral, and anticancer agents.
Used in Agrochemical Industry:
5-Chloro-2-cyanopyridine is also utilized in the agrochemical industry for the development of new pesticides and herbicides. Its chemical properties allow for the design of innovative molecules with improved efficacy and selectivity, contributing to more effective and environmentally friendly crop protection solutions.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 5-Chloro-2-cyanopyridine is employed as a precursor for the synthesis of various dyes and pigments. Its ability to form stable chromophores and participate in conjugated systems makes it suitable for the production of colorants with high color strength, stability, and fastness properties.
Used in Research and Development:
5-Chloro-2-cyanopyridine is used as a research compound in academic and industrial laboratories. Its unique structure and reactivity make it an interesting subject for studying various chemical reactions and mechanisms, as well as for exploring its potential applications in materials science, catalysis, and other fields.
Check Digit Verification of cas no
The CAS Registry Mumber 89809-64-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,8,0 and 9 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 89809-64:
(7*8)+(6*9)+(5*8)+(4*0)+(3*9)+(2*6)+(1*4)=193
193 % 10 = 3
So 89809-64-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H3ClN2/c7-5-1-2-6(3-8)9-4-5/h1-2,4H
89809-64-3Relevant articles and documents
A Transition-Metal-Free One-Pot Cascade Process for Transformation of Primary Alcohols (RCH2OH) to Nitriles (RCN) Mediated by SO2F2
Jiang, Ying,Sun, Bing,Fang, Wan-Yin,Qin, Hua-Li
, p. 3190 - 3194 (2019/05/21)
A new transition-metal-free one-pot cascade process for the direct conversion of alcohols to nitriles was developed without introducing an “additional carbon atom”. This protocol allows transformations of readily available, inexpensive, and abundant alcohols to highly valuable nitriles.
HYDRAZONE COMPOUNDS AND THEIR USE
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Page/Page column 131-132, (2010/12/17)
The present invention relates to hydrazone compounds of Formula I: (I) and pharmaceutically acceptable salts and stereoisomers thereof, wherein R1, R2, R3, R4, L1, and L2 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I as inhibitors of TRPM5 protein.
Discovery and structure-activity relationship of 3-aryl-5-aryl-1,2,4- oxadiazoles as a new series of apoptosis inducers and potential anticancer agents
Zhang, Han-Zhong,Kasibhatla, Shailaja,Kuemmerle, Jared,Kemnitzer, William,Ollis-Mason, Kristin,Qiu, Ling,Crogan-Grundy, Candace,Tseng, Ben,Drewe, John,Cai, Sui Xiong
, p. 5215 - 5223 (2007/10/03)
We have identified 5-(3-chlorothiophen-2-yl)-3-(4-trifluoromethylphenyl)-1, 2,4-oxadiazole (1d) as a novel apoptosis inducer through our caspase- and cell-based high-throughput screening assay. Compound 1d has good activity against several breast and colorectal cancer cell lines but is inactive against several other cancer cell lines. In a flow cytometry assay, treatment of T47D cells with 1d resulted in arrest of cells in the G1 phase, followed by induction of apoptosis. SAR studies of Id showed that the 3-phenyl group can be replaced by a pyridyl group, and a substituted five-member ring in the 5-position is important for activity. 5-(3-Chlorothiophen-2-yl)-3-(5- chloropyridin-2-yl)-1,2,4-oxadiazole (41) has been found to have in vivo activity in a MX-1 tumor model. Using a photoaffinity agent, the molecular target has been identified as TIP47, an IGFII receptor binding protein. Therefore, our cell-based chemical genetics approach for the discovery of apoptosis inducers can identify potential anticancer agents as well as their molecular targets.
