(E)-methyl 3-(2-chlorophenyl)-2-{[4-methyl-N-(3-methylbut-2-enyl)phenylsulfonamido]methyl}prop-2-enoate

Base Information

• Chemical Name: (E)-methyl 3-(2-chlorophenyl)-2-{[4-methyl-N-(3-methylbut-2-enyl)phenylsulfonamido]methyl}prop-2-enoate
• CAS No.: 1361384-93-1
• Molecular Formula: C₂₃H₂₆ClNO₄S
• Molecular Weight: 447.983
• Mol file: 1361384-93-1.mol

Synonyms:(E)-methyl 3-(2-chlorophenyl)-2-{[4-methyl-N-(3-methylbut-2-enyl)phenylsulfonamido]methyl}prop-2-enoate

Chemical Property of (E)-methyl 3-(2-chlorophenyl)-2-{[4-methyl-N-(3-methylbut-2-enyl)phenylsulfonamido]methyl}prop-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-methyl 3-(2-chlorophenyl)-2-{[4-methyl-N-(3-methylbut-2-enyl)phenylsulfonamido]methyl}prop-2-enoate

There total 1 articles about (E)-methyl 3-(2-chlorophenyl)-2-{[4-methyl-N-(3-methylbut-2-enyl)phenylsulfonamido]methyl}prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

C18H18ClNO4S (1361384-91-9) + prenyl bromide (870-63-3) → (E)-methyl 3-(2-chlorophenyl)-2-{[4-methyl-N-(3-methylbut-2-enyl)phenylsulfonamido]methyl}prop-2-enoate (1361384-93-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 2h;

DOI:10.1016/j.tet.2012.01.016

Reference yield: 80.0%

(E)-methyl 3-(2-chlorophenyl)-2-{[4-methyl-N-(3-methylbut-2-enyl)phenylsulfonamido]methyl}prop-2-enoate (1361384-93-1) → (E)-2-{[(N-(3-methylbut-2-en-1-yl))(N-tosyl)amino]methyl}-3-(2-chlorophenyl)prop-2-en-1-ol (1361384-95-3)

Guidance literature:

(E)-methyl 3-(2-chlorophenyl)-2-{[4-methyl-N-(3-methylbut-2-enyl)phenylsulfonamido]methyl}prop-2-enoate; With diisobutylaluminium hydride; In toluene; for 0.5h; Inert atmosphere;

With methanol; In toluene; Inert atmosphere;

DOI:10.1016/j.tet.2012.01.016

Reference yield:

(E)-methyl 3-(2-chlorophenyl)-2-{[4-methyl-N-(3-methylbut-2-enyl)phenylsulfonamido]methyl}prop-2-enoate (1361384-93-1) → (E)-2-{[(N-(3-methylbut-2-en-1-yl))(N-tosyl)amino]methyl}-3-(2-chlorophenyl)prop-2-enal (1361384-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / toluene / 0.5 h / Inert atmosphere

1.2: Inert atmosphere

2.1: manganese(IV) oxide / dichloromethane / 1 h

With manganese(IV) oxide; diisobutylaluminium hydride; In dichloromethane; toluene;

DOI:10.1016/j.tet.2012.01.016

upstream raw materials:

C₁₈H₁₈ClNO₄S

prenyl bromide

Downstream raw materials:

(E)-2-{[(N-(3-methylbut-2-en-1-yl))(N-tosyl)amino]methyl}-3-(2-chlorophenyl)prop-2-en-1-ol

(E)-2-{[(N-(3-methylbut-2-en-1-yl))(N-tosyl)amino]methyl}-3-(2-chlorophenyl)prop-2-enal