(E)-2-{[(N-(3-methylbut-2-en-1-yl))(N-tosyl)amino]methyl}-3-(2-chlorophenyl)prop-2-enal

Base Information

• Chemical Name: (E)-2-{[(N-(3-methylbut-2-en-1-yl))(N-tosyl)amino]methyl}-3-(2-chlorophenyl)prop-2-enal
• CAS No.: 1361384-97-5
• Molecular Formula: C₂₂H₂₄ClNO₃S
• Molecular Weight: 417.956
• Mol file: 1361384-97-5.mol

Synonyms:(E)-2-{[(N-(3-methylbut-2-en-1-yl))(N-tosyl)amino]methyl}-3-(2-chlorophenyl)prop-2-enal

Chemical Property of (E)-2-{[(N-(3-methylbut-2-en-1-yl))(N-tosyl)amino]methyl}-3-(2-chlorophenyl)prop-2-enal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-{[(N-(3-methylbut-2-en-1-yl))(N-tosyl)amino]methyl}-3-(2-chlorophenyl)prop-2-enal

There total 4 articles about (E)-2-{[(N-(3-methylbut-2-en-1-yl))(N-tosyl)amino]methyl}-3-(2-chlorophenyl)prop-2-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(E)-2-{[(N-(3-methylbut-2-en-1-yl))(N-tosyl)amino]methyl}-3-(2-chlorophenyl)prop-2-en-1-ol (1361384-95-3) → (E)-2-{[(N-(3-methylbut-2-en-1-yl))(N-tosyl)amino]methyl}-3-(2-chlorophenyl)prop-2-enal (1361384-97-5)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 1h;

DOI:10.1016/j.tet.2012.01.016

Reference yield:

(E)-methyl 3-(2-chlorophenyl)-2-{[4-methyl-N-(3-methylbut-2-enyl)phenylsulfonamido]methyl}prop-2-enoate (1361384-93-1) → (E)-2-{[(N-(3-methylbut-2-en-1-yl))(N-tosyl)amino]methyl}-3-(2-chlorophenyl)prop-2-enal (1361384-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / toluene / 0.5 h / Inert atmosphere

1.2: Inert atmosphere

2.1: manganese(IV) oxide / dichloromethane / 1 h

With manganese(IV) oxide; diisobutylaluminium hydride; In dichloromethane; toluene;

DOI:10.1016/j.tet.2012.01.016

Reference yield:

C18H18ClNO4S (1361384-91-9) → (E)-2-{[(N-(3-methylbut-2-en-1-yl))(N-tosyl)amino]methyl}-3-(2-chlorophenyl)prop-2-enal (1361384-97-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h

2.1: diisobutylaluminium hydride / toluene / 0.5 h / Inert atmosphere

2.2: Inert atmosphere

3.1: manganese(IV) oxide / dichloromethane / 1 h

With manganese(IV) oxide; diisobutylaluminium hydride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.tet.2012.01.016

upstream raw materials:

(E)-methyl 3-(2-chlorophenyl)-2-{[4-methyl-N-(3-methylbut-2-enyl)phenylsulfonamido]methyl}prop-2-enoate

C₁₈H₁₈ClNO₄S

(E)-2-{[(N-(3-methylbut-2-en-1-yl))(N-tosyl)amino]methyl}-3-(2-chlorophenyl)prop-2-en-1-ol

prenyl bromide