2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

Base Information

Chemical Name:2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide
CAS No.:1245940-74-2
Molecular Formula:C₂₃H₂₀ClF₆N₅O₄
Molecular Weight:579.886
Hs Code.:

2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

Synonyms:2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

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Chemical Property of 2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

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Technology Process of 2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

There total 11 articles about 2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1245940-73-1
2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanoic acid

: 1245940-74-2
2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

Guidance literature:: 2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanoic acid; With N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

With ammonia; In water; N,N-dimethyl-formamide;

Reference yield:

: 1134679-10-9
2-amino-2-[3-(trifluoromethyl)phenyl]propanoic acid

: 1245940-74-2
2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 0.33 h / 20 °C

2: benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 0.33 h / 20 °C

With N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield:

: 536-40-3
4-chlorobenzoic acid hydrazide

: 1245940-74-2
2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrahydrofuran / 20 - 50 °C

2.1: sodium hydroxide; water / Reflux

2.2: pH 1

3.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

3.2: 70 °C

4.1: sodium tetrahydroborate / methanol / 1.5 h / Cooling with ice

5.1: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

6.1: ethyl acetate; 2-Methylpentane / Resolution of racemate

7.1: lithium hydroxide / water; methanol / 1 h / 20 °C

7.2: pH 1 - 2

8.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 0.33 h / 20 °C

9.1: benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 0.33 h / 20 °C

With sodium tetrahydroborate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; water; potassium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; potassium iodide; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; pyridine; methanol; 2-Methylpentane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;