5-((10H-phenothiazin-10-yl)methyl)-4-(4-chlorobenzylideneamino)-4H-1,2,4-triazole-3-thiol

Base Information

• Chemical Name: 5-((10H-phenothiazin-10-yl)methyl)-4-(4-chlorobenzylideneamino)-4H-1,2,4-triazole-3-thiol
• CAS No.: 942031-73-4
• Molecular Formula: C₂₂H₁₆ClN₅S₂
• Molecular Weight: 449.988
• Mol file: 942031-73-4.mol

Synonyms:5-((10H-phenothiazin-10-yl)methyl)-4-(4-chlorobenzylideneamino)-4H-1,2,4-triazole-3-thiol

Chemical Property of 5-((10H-phenothiazin-10-yl)methyl)-4-(4-chlorobenzylideneamino)-4H-1,2,4-triazole-3-thiol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-((10H-phenothiazin-10-yl)methyl)-4-(4-chlorobenzylideneamino)-4H-1,2,4-triazole-3-thiol

There total 3 articles about 5-((10H-phenothiazin-10-yl)methyl)-4-(4-chlorobenzylideneamino)-4H-1,2,4-triazole-3-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-((10H-phenothiazin-10-yl)methyl)-4-amino-4H-1,2,4-triazole-3-thiol + 4-chlorobenzaldehyde (104-88-1) → 5-((10H-phenothiazin-10-yl)methyl)-4-(4-chlorobenzylideneamino)-4H-1,2,4-triazole-3-thiol (942031-73-4)

Guidance literature:

With sulfuric acid; In N,N-dimethyl-formamide; at 25 ℃;

DOI:10.4067/s0717-97072015000200012

Reference yield:

10H-phenothiazine (92-84-2) → 5-((10H-phenothiazin-10-yl)methyl)-4-(4-chlorobenzylideneamino)-4H-1,2,4-triazole-3-thiol (942031-73-4)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 78 °C / Reflux

2: potassium hydroxide; water / ethanol / 12 h / 25 °C

3: neat (no solvent) / Heating

4: sulfuric acid / N,N-dimethyl-formamide / 25 °C

With sulfuric acid; water; potassium carbonate; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; acetone;

DOI:10.4067/s0717-97072015000200012

Reference yield:

2-(10H-phenothiazin-10-yl)acetic acid (25244-68-2) → 5-((10H-phenothiazin-10-yl)methyl)-4-(4-chlorobenzylideneamino)-4H-1,2,4-triazole-3-thiol (942031-73-4)

Guidance literature:

Multi-step reaction with 2 steps

1: neat (no solvent) / Heating

2: sulfuric acid / N,N-dimethyl-formamide / 25 °C

With sulfuric acid; In N,N-dimethyl-formamide;

DOI:10.4067/s0717-97072015000200012

upstream raw materials:

10H-phenothiazine

2-(10H-phenothiazin-10-yl)acetic acid

4-chlorobenzaldehyde