(Z)-3-(4,5-difluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-N-methyl-benzene-sulphonamide

Base Information

Chemical Name:(Z)-3-(4,5-difluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-N-methyl-benzene-sulphonamide
CAS No.:1421507-30-3
Molecular Formula:C₁₆H₁₂F₂N₂O₃S
Molecular Weight:350.346
Hs Code.:

Synonyms:(Z)-3-(4,5-difluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-N-methyl-benzene-sulphonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-3-(4,5-difluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-N-methyl-benzene-sulphonamide

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Technology Process of (Z)-3-(4,5-difluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-N-methyl-benzene-sulphonamide

There total 5 articles about (Z)-3-(4,5-difluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-N-methyl-benzene-sulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 132390-65-9
3-formyl-N-methyl-benzenesulfonamide

: 850429-64-0
4,5-difluoro-2-oxindole

: 1421507-30-3
(Z)-3-(4,5-difluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-N-methyl-benzene-sulphonamide

Guidance literature:: With piperidine; In ethanol; at 140 ℃; for 0.25h; Microwave irradiation; Sealed tube;
DOI:10.1002/cmdc.201500235

Reference yield: 44.7%

: 1421507-30-3
(Z)-3-(4,5-difluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-N-methyl-benzene-sulphonamide

Guidance literature:: With piperidine; In ethanol; at 140 ℃; for 0.25h; Sealed tube; Microwave irradiation;

Reference yield:

: 4025-64-3
3-Carboxybenzenesulfonyl chloride

: 1421507-30-3
(Z)-3-(4,5-difluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-N-methyl-benzene-sulphonamide

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / ethyl acetate; water / 0.5 h / 0 °C

2: borane-THF / tetrahydrofuran / 15 h / 25 °C

3: dipyridinium dichromate / tetrahydrofuran / 6 h / 25 °C

4: piperidine / ethanol / 0.25 h / 140 °C / Microwave irradiation; Sealed tube

With piperidine; dipyridinium dichromate; borane-THF; ammonia; In tetrahydrofuran; ethanol; water; ethyl acetate;
DOI:10.1002/cmdc.201500235