Technology Process of 5-bromo-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide
There total 3 articles about 5-bromo-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid / chloroform / 18 h / 0 - 50 °C
2.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.08 h / 0 °C
2.2: 3 h / 5 - 20 °C
3.1: triethylamine / 1,2-dichloro-ethane / 42 h / 80 °C
4.1: trifluoroacetic anhydride; urea hydrogen peroxide adduct / acetonitrile / 20 °C
With
boron trifluoride diethyl etherate; urea hydrogen peroxide adduct; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride;
In
tetrahydrofuran; chloroform; 1,2-dichloro-ethane; acetonitrile;
1.1: |Fischer Indole Synthesis;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.08 h / -45 - -30 °C
1.2: 1 h / 20 °C
2.1: trifluoroacetic acid / chloroform / 18 h / 0 - 50 °C
3.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.08 h / 0 °C
3.2: 3 h / 5 - 20 °C
4.1: triethylamine / 1,2-dichloro-ethane / 42 h / 80 °C
5.1: trifluoroacetic anhydride; urea hydrogen peroxide adduct / acetonitrile / 20 °C
With
oxalyl dichloride; boron trifluoride diethyl etherate; urea hydrogen peroxide adduct; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride;
In
tetrahydrofuran; dichloromethane; chloroform; 1,2-dichloro-ethane; acetonitrile;
1.1: |Swern Oxidation / 1.2: |Swern Oxidation / 2.1: |Fischer Indole Synthesis;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid / chloroform / 18 h / 0 - 50 °C
2.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.08 h / 0 °C
2.2: 3 h / 5 - 20 °C
3.1: triethylamine / 1,2-dichloro-ethane / 42 h / 80 °C
4.1: trifluoroacetic anhydride; urea hydrogen peroxide adduct / acetonitrile / 20 °C
With
boron trifluoride diethyl etherate; urea hydrogen peroxide adduct; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride;
In
tetrahydrofuran; chloroform; 1,2-dichloro-ethane; acetonitrile;
1.1: |Fischer Indole Synthesis;
