50675-19-9

Basic information

• Product Name: Tetrahydrothiopyran-4-carbaldehyde
• Synonyms: 4-THIANYLCARBALDEHYDE;2H-Thiopyran-4-carboxaldehyde, tetrahydro-;Tetrahydro-2H-thiopyran-4-carboxaldehyde 97%;Tetrahydro-2H-thiopyran-4-carboxaldehyde;Tetrahydrothiopyran-4-carbaldehyde;Tetrahydrothiopyranyl-4-carboxaldehyde;4-Formyltetrahydro-2H-thiopyran;thiane-4-carbaldehyde
• CAS NO: 50675-19-9
• Molecular Formula: C₆H₁₀OS
• Molecular Weight: 130.21
• Mol File: 50675-19-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 217 °C at 760 mmHg
• Flash Point: 97.2 °C
• Appearance: /
• Density: 1.157 g/cm³
• Vapor Pressure: 0.136mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: Tetrahydrothiopyran-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydrothiopyran-4-carbaldehyde(50675-19-9)
• EPA Substance Registry System: Tetrahydrothiopyran-4-carbaldehyde(50675-19-9)

Safety Data

• Hazardous Substances Data: 50675-19-9(Hazardous Substances Data)

Usage

General Description

Tetrahydrothiopyran-4-carbaldehyde, also known as 4-hydroxy-3,3-dimethyl-2,7-dioxabicyclo[2.2.1]heptan-5-one, is a chemical compound represented by the molecular formula C6H10OS. Its systematic name is 2H,5H-1,4,2-thiazepine 5,5-dioxide, according to the International Union of Pure and Applied Chemistry (IUPAC). It is categorized under the organosulfur compounds group with a molecular weight of approximately 130.21 g/mol. The detailed physical, chemical, or toxicological properties of this compound are not well-documented in scientific literature. In terms of its usual applications, specific information is currently limited. However, like other organosulfur compounds, it could be utilized in various chemical reactions and processes.

InChI:InChI=1/C6H10OS/c7-5-6-1-3-8-4-2-6/h5-6H,1-4H2

Upstream product

• 100277-27-8 (tetrahydro-2H-thiopyran-4-yl)methanol 
• 79-37-8 oxalyl dichloride 
• 131992-30-8 4-(methoxymethylene)-3,4,5,6-tetrahydro-2H-thiopyran 
• 195503-40-3 tetrahydro-2H-thiopyrane-4-carbonitrile 
• 89489-53-2 tetrahydro-2H-thiopyran-4-carboxylic acid 
• 50-00-0 formaldehyd 
• 1072-72-6 Tetrahydrothiopyran-4-one 

Downstream Products

• 195503-40-3 tetrahydro-2H-thiopyrane-4-carbonitrile 
• 1100509-34-9 4-ethynyltetrahydro-2H-thiopyran 
• 494210-61-6 1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-carbaldehyde 
• 1174540-28-3 2-((R)-(1-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methylamino)ethyl)-3-(4-chlorophenyl)pyrido[2,3d]pyrimidin-4(3H)-one 
• 1262797-01-2 C₃₀H₂₇ClF₄N₄O₄S 
• 1360889-95-7 C₂₅H₂₆N₄S 
• 1448039-40-4 2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]-5-amine 1',1'-dioxide 
• 100277-27-8 (tetrahydro-2H-thiopyran-4-yl)methanol 
• 1221501-74-1 6-[5-(4-Fluorophenyl)-3-methyl-1-(tetrahydro-2H-thiopyran-4-ylmethyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one 
• 1221504-17-1 4-bromo-5-(4-fluorophenyl)-3-methyl-1-(tetrahydro-2H-thiopyran-4-ylmethyl)-1H-pyrazole 
• 1557245-00-7 4-nitro-1-[phenyl(tetrahydro-2H-thiopyran-4-yl)methyl]-1H-pyrazole 

Relevant articles and documents

Expansion of substrate scope for nitroxyl radical/copper-catalyzed aerobic oxidation of primary alcohols: A guideline for catalyst selection

Four distinctive sets of optimum nitroxyl radical/copper salt/additive catalyst combinations have been identified for accommodating the aerobic oxidation of various types of primary alcohols to their corresponding aldehydes. Interestingly, less nucleophilic catalysts exhibited higher catalytic activities for the oxidation of particular primary allylic and propargylic alcohols to give α,β-unsaturated aldehydes that function as competent Michael acceptors. The optimum conditions identified herein were successful in the oxidation of various types of primary alcohols, including unprotected amino alcohols and divalent-sulfur-containing alcohols in good-to-high yields. Moreover, N-protected alaninol, an inefficient substrate in the nitroxyl radical/ copper-catalyzed aerobic oxidation, was oxidized in good yield. On the basis of the optimization results, a guideline for catalyst selection has been established.

Azacyclo diketone compound and preparation method thereof

The invention provides an azacyclo diketone compound, which is a compound represented by the following structure defined in the specification, or a pharmaceutically acceptable salt thereof. The invention provides a compound having an inhibitory activity on influenza (flu) virus proliferation, particularly on influenza-related cap-dependent endonuclease to inhibit influenza virus proliferation so as to treat or prevent influenza. The present invention relates to a substituted azacyclo diketone compound having inhibitory activity on cap-dependent endonuclease, and a pharmaceutical composition containing the substituted azacyclo diketone compound.

Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow

Cheap and readily available aqueous formaldehyde was used as a formylating reagent in a homologation reaction with nonstabilized diazo compounds, enabled by UV photolysis of bench-stable oxadiazolines in a flow photoreactor. Various aliphatic aldehydes were synthesized along with the corresponding derivatized alcohols and benzimidazoles. No transition-metal catalyst or additive was required to affect the reaction, which proceeded at room temperature in 80 min.