(5S,13S)-21-Allyloxy-19-bromo-5,13-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene

Base Information

• Chemical Name: (5S,13S)-21-Allyloxy-19-bromo-5,13-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene
• CAS No.: 857682-70-3
• Molecular Formula: C₃₁H₃₅BrO₆
• Molecular Weight: 583.519

Synonyms:(5S,13S)-21-Allyloxy-19-bromo-5,13-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene

Chemical Property of (5S,13S)-21-Allyloxy-19-bromo-5,13-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene

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Technology Process of (5S,13S)-21-Allyloxy-19-bromo-5,13-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene

There total 4 articles about (5S,13S)-21-Allyloxy-19-bromo-5,13-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.2%

(S)-2-[2-Allyloxy-5-bromo-3-((S)-2-hydroxy-2-phenyl-ethoxymethyl)-benzyloxy]-1-phenyl-ethanol (857682-69-0) + diethylene glycol ditosylate (7460-82-4) → (5S,13S)-21-Allyloxy-19-bromo-5,13-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1(20),17(21),18-triene (857682-70-3)

Guidance literature:

With sodium hydride; potassium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 - 40 ℃; for 27h;

DOI:10.1021/jo050387u

Reference yield:

C37H45BrO7 → (5S,13S)-21-Allyloxy-19-bromo-5,13-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1(20),17(21),18-triene (857682-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 5.57 g / HCl / methanol; tetrahydrofuran / 10.5 h / 20 °C

2: 36.2 percent / NaH; KBF₄ / dimethylformamide / 27 h / 20 - 40 °C

With hydrogenchloride; sodium hydride; potassium tetrafluoroborate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jo050387u

Reference yield:

(S)-(+)-2-phenyl-2-(tetrahydropyranyloxy)ethanol (94199-20-9) → (5S,13S)-21-Allyloxy-19-bromo-5,13-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1(20),17(21),18-triene (857682-70-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / dimethylformamide / 6.5 h / 20 - 40 °C

2: 5.57 g / HCl / methanol; tetrahydrofuran / 10.5 h / 20 °C

3: 36.2 percent / NaH; KBF₄ / dimethylformamide / 27 h / 20 - 40 °C

With hydrogenchloride; sodium hydride; potassium tetrafluoroborate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jo050387u

upstream raw materials:

(S)-2-[2-Allyloxy-5-bromo-3-((S)-2-hydroxy-2-phenyl-ethoxymethyl)-benzyloxy]-1-phenyl-ethanol

diethylene glycol ditosylate

(S)-(+)-2-phenyl-2-(tetrahydropyranyloxy)ethanol

2-allyloxy-5-bromo-1,3-bis-chloromethyl-benzene

Downstream raw materials:

3,3-Bis-((5S,13S)-21-allyloxy-5,13-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-trien-19-yl)-3H-isobenzofuran-1-one

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