(1S,2S)-2-amino-2-(4-chlorophenyl)-1-(N-boc-amino)-1-(4-methylphenyl)ethane

Base Information

Chemical Name:(1S,2S)-2-amino-2-(4-chlorophenyl)-1-(N-boc-amino)-1-(4-methylphenyl)ethane
CAS No.:1293372-56-1
Molecular Formula:C₂₀H₂₅ClN₂O₂
Molecular Weight:360.884
Hs Code.:

Synonyms:(1S,2S)-2-amino-2-(4-chlorophenyl)-1-(N-boc-amino)-1-(4-methylphenyl)ethane

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Chemical Property of (1S,2S)-2-amino-2-(4-chlorophenyl)-1-(N-boc-amino)-1-(4-methylphenyl)ethane

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Technology Process of (1S,2S)-2-amino-2-(4-chlorophenyl)-1-(N-boc-amino)-1-(4-methylphenyl)ethane

There total 5 articles about (1S,2S)-2-amino-2-(4-chlorophenyl)-1-(N-boc-amino)-1-(4-methylphenyl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1293372-61-8
(1S,2S)-N-boc-2-azido-2-(4-chlorophenyl)-1-(4-methylphenyl)-ethyl amine

: 1293372-56-1
(1S,2S)-2-amino-2-(4-chlorophenyl)-1-(N-boc-amino)-1-(4-methylphenyl)ethane

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 12h;
DOI:10.1039/c0cc05289b

Reference yield:

: 1293372-42-5
4-(4-methylphenyl)-5-(4-chlorophenyl)-5H-[1,2,3]oxathiazole 2,2-dioxide

: 1293372-56-1
(1S,2S)-2-amino-2-(4-chlorophenyl)-1-(N-boc-amino)-1-(4-methylphenyl)ethane

Guidance literature:: Multi-step reaction with 4 steps

1.1: formic acid; RhCl[(R,R)-TsDPEN](C₅Me₅); triethylamine / ethyl acetate / 0.5 h / 25 °C / Inert atmosphere

2.1: dmap / dichloromethane / 1 h / 25 °C / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 5 h / 60 °C / Inert atmosphere

3.2: 12 h / 25 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h

With dmap; formic acid; sodium azide; RhCl[(R,R)-TsDPEN](C₅Me₅); palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/c0cc05289b

Reference yield:

: 1293372-54-9
(4S,5R)-4-(4-methylphenyl)-5-(4-chlorophenyl)-[1,2,3]oxathiazolidine 2,2-dioxide

: 1293372-56-1
(1S,2S)-2-amino-2-(4-chlorophenyl)-1-(N-boc-amino)-1-(4-methylphenyl)ethane

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / dichloromethane / 1 h / 25 °C / Inert atmosphere

2.1: sodium azide / N,N-dimethyl-formamide / 5 h / 60 °C / Inert atmosphere

2.2: 12 h / 25 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h

With dmap; sodium azide; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0cc05289b