(1S,2S)-N-boc-2-azido-2-(4-chlorophenyl)-1-(4-methylphenyl)-ethyl amine

Base Information

Chemical Name:(1S,2S)-N-boc-2-azido-2-(4-chlorophenyl)-1-(4-methylphenyl)-ethyl amine
CAS No.:1293372-61-8
Molecular Formula:C₂₀H₂₃ClN₄O₂
Molecular Weight:386.881
Hs Code.:

Synonyms:(1S,2S)-N-boc-2-azido-2-(4-chlorophenyl)-1-(4-methylphenyl)-ethyl amine

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Chemical Property of (1S,2S)-N-boc-2-azido-2-(4-chlorophenyl)-1-(4-methylphenyl)-ethyl amine

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Technology Process of (1S,2S)-N-boc-2-azido-2-(4-chlorophenyl)-1-(4-methylphenyl)-ethyl amine

There total 4 articles about (1S,2S)-N-boc-2-azido-2-(4-chlorophenyl)-1-(4-methylphenyl)-ethyl amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1293372-55-0
(4S,5R)-N-boc-4-(4-methylphenyl)-5-(4-chlorophenyl)-[1,2,3]oxathiazolidine 2,2-dioxide

: 1293372-61-8
(1S,2S)-N-boc-2-azido-2-(4-chlorophenyl)-1-(4-methylphenyl)-ethyl amine

Guidance literature:: (4S,5R)-N-boc-4-(4-methylphenyl)-5-(4-chlorophenyl)-[1,2,3]oxathiazolidine 2,2-dioxide; With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 5h; Inert atmosphere;

With hydrogenchloride; water; In diethyl ether; N,N-dimethyl-formamide; at 25 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c0cc05289b

Reference yield:

: 1293372-42-5
4-(4-methylphenyl)-5-(4-chlorophenyl)-5H-[1,2,3]oxathiazole 2,2-dioxide

: 1293372-61-8
(1S,2S)-N-boc-2-azido-2-(4-chlorophenyl)-1-(4-methylphenyl)-ethyl amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: formic acid; RhCl[(R,R)-TsDPEN](C₅Me₅); triethylamine / ethyl acetate / 0.5 h / 25 °C / Inert atmosphere

2.1: dmap / dichloromethane / 1 h / 25 °C / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 5 h / 60 °C / Inert atmosphere

3.2: 12 h / 25 °C / Inert atmosphere

With dmap; formic acid; sodium azide; RhCl[(R,R)-TsDPEN](C₅Me₅); triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/c0cc05289b

Reference yield:

: 1293372-54-9
(4S,5R)-4-(4-methylphenyl)-5-(4-chlorophenyl)-[1,2,3]oxathiazolidine 2,2-dioxide

: 1293372-61-8
(1S,2S)-N-boc-2-azido-2-(4-chlorophenyl)-1-(4-methylphenyl)-ethyl amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / dichloromethane / 1 h / 25 °C / Inert atmosphere

2.1: sodium azide / N,N-dimethyl-formamide / 5 h / 60 °C / Inert atmosphere

2.2: 12 h / 25 °C / Inert atmosphere

With dmap; sodium azide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0cc05289b