N-[2-(4-amino-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

Base Information

Chemical Name:N-[2-(4-amino-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt
CAS No.:1365990-59-5
Molecular Formula:C₁₆H₁₁Cl₂N₇S*ClH
Molecular Weight:440.743
Hs Code.:

Synonyms:N-[2-(4-amino-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

Suppliers and Price of N-[2-(4-amino-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[2-(4-amino-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[2-(4-amino-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

There total 10 articles about N-[2-(4-amino-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1365992-35-3
C₃₁H₃₅Cl₂N₇O₆S

: 1365990-59-5
N-[2-(4-amino-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 50 ℃; for 3h; Inert atmosphere;

Reference yield:

: 628691-93-0
2-chloro-3-fluoro-pyridine-4-carboxylic acid

: 1365990-59-5
N-[2-(4-amino-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: diphenyl phosphoryl azide / toluene / 3 h / 110 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2.2: NH₂ cartridge

3.1: triethylamine / 1,4-dioxane / 18 h / 100 °C

4.1: thionyl chloride / 56 h / 90 °C

5.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / 90 °C

5.2: 1.5 h / 90 °C

6.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 20 h / 85 - 100 °C / Inert atmosphere; Microwave irradiation

7.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 25 h / 20 - 80 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 3 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; potassium phosphate; thionyl chloride; diphenyl phosphoryl azide; caesium carbonate; triethylamine; thiourea; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; water; isopropyl alcohol; toluene;

Reference yield:

: 1258298-01-9
2,6-dichloro-4-iodo-benzoic acid

: 1365990-59-5
N-[2-(4-amino-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine / 1,4-dioxane / 18 h / 100 °C

3.1: thionyl chloride / 56 h / 90 °C

4.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / 90 °C

4.2: 1.5 h / 90 °C

5.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 20 h / 85 - 100 °C / Inert atmosphere; Microwave irradiation

6.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 25 h / 20 - 80 °C / Inert atmosphere

7.1: hydrogenchloride / 1,4-dioxane / 3 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; potassium phosphate; thionyl chloride; caesium carbonate; triethylamine; thiourea; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; isopropyl alcohol; toluene;