1-(1,1-dimethylethyl) 3-methyl 6-(4-hydroxyphenyl)-1H-indazole-1,3-dicarboxylate

Base Information

Chemical Name:1-(1,1-dimethylethyl) 3-methyl 6-(4-hydroxyphenyl)-1H-indazole-1,3-dicarboxylate
CAS No.:1093631-78-7
Molecular Formula:C₂₀H₂₀N₂O₅
Molecular Weight:368.389
Hs Code.:

Synonyms:1-(1,1-dimethylethyl) 3-methyl 6-(4-hydroxyphenyl)-1H-indazole-1,3-dicarboxylate

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Chemical Property of 1-(1,1-dimethylethyl) 3-methyl 6-(4-hydroxyphenyl)-1H-indazole-1,3-dicarboxylate

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Technology Process of 1-(1,1-dimethylethyl) 3-methyl 6-(4-hydroxyphenyl)-1H-indazole-1,3-dicarboxylate

There total 5 articles about 1-(1,1-dimethylethyl) 3-methyl 6-(4-hydroxyphenyl)-1H-indazole-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3460-18-2
1,4-dibromo-2-nitrobenzene

: 1093631-78-7
1-(1,1-dimethylethyl) 3-methyl 6-(4-hydroxyphenyl)-1H-indazole-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.42 h / 20 °C

1.2: 21 h / 0 - 120 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 2 h / 70 °C

3.1: hydrogen; acetic acid / palladium 10% on activated carbon / water / 2 h / 20 °C / 1551.49 Torr

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 40 °C

5.1: tert.-butylnitrite; acetic acid / 16 h / 80 °C

5.2: 0.08 h / 0 °C

6.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

With dmap; tert.-butylnitrite; hydrogen; sodium hydride; potassium carbonate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 2.1: Suzuki Coupling;

Reference yield:

: 100487-82-9
4-bromo-2-nitro-benzoic acid methyl ester

: 1093631-78-7
1-(1,1-dimethylethyl) 3-methyl 6-(4-hydroxyphenyl)-1H-indazole-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 2 h / 70 °C

2.1: hydrogen; acetic acid / palladium 10% on activated carbon / water / 2 h / 20 °C / 1551.49 Torr

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 40 °C

4.1: tert.-butylnitrite; acetic acid / 16 h / 80 °C

4.2: 0.08 h / 0 °C

5.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

With dmap; tert.-butylnitrite; hydrogen; potassium carbonate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Suzuki Coupling;

Reference yield:

: 1093631-76-5
methyl {3-nitro-4'-[(phenylmethyl)oxy]-4-biphenylyl}acetate

: 1093631-78-7
1-(1,1-dimethylethyl) 3-methyl 6-(4-hydroxyphenyl)-1H-indazole-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; acetic acid / palladium 10% on activated carbon / water / 2 h / 20 °C / 1551.49 Torr

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 40 °C

3.1: tert.-butylnitrite; acetic acid / 16 h / 80 °C

3.2: 0.08 h / 0 °C

4.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

With dmap; tert.-butylnitrite; hydrogen; potassium carbonate; acetic acid; triethylamine; palladium 10% on activated carbon; In dichloromethane; water; N,N-dimethyl-formamide;