6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-indazole-3-carboxylic acid

Base Information

Chemical Name:6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-indazole-3-carboxylic acid
CAS No.:1093631-49-2
Molecular Formula:C₂₇H₂₁Cl₂N₃O₄
Molecular Weight:522.387
Hs Code.:

Synonyms:6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-indazole-3-carboxylic acid

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Chemical Property of 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-indazole-3-carboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-indazole-3-carboxylic acid

There total 8 articles about 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-indazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 700835-81-0
4-(chloromethyl)-3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole

: 1093631-78-7
1-(1,1-dimethylethyl) 3-methyl 6-(4-hydroxyphenyl)-1H-indazole-1,3-dicarboxylate

: 1093631-49-2
6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-indazole-3-carboxylic acid

Guidance literature:: 4-(chloromethyl)-3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole; 1-(1,1-dimethylethyl) 3-methyl 6-(4-hydroxyphenyl)-1H-indazole-1,3-dicarboxylate; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 50 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; ethanol; water;

Reference yield:

: 3460-18-2
1,4-dibromo-2-nitrobenzene

: 1093631-49-2
6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-indazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.42 h / 20 °C

1.2: 21 h / 0 - 120 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 2 h / 70 °C

3.1: hydrogen; acetic acid / palladium 10% on activated carbon / water / 2 h / 20 °C / 1551.49 Torr

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 40 °C

5.1: tert.-butylnitrite; acetic acid / 16 h / 80 °C

5.2: 0.08 h / 0 °C

6.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

7.2: 2 h / 50 °C

With dmap; tert.-butylnitrite; hydrogen; sodium hydride; potassium carbonate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 2.1: Suzuki Coupling;

Reference yield:

: 100487-82-9
4-bromo-2-nitro-benzoic acid methyl ester

: 1093631-49-2
6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-indazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 2 h / 70 °C

2.1: hydrogen; acetic acid / palladium 10% on activated carbon / water / 2 h / 20 °C / 1551.49 Torr

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 40 °C

4.1: tert.-butylnitrite; acetic acid / 16 h / 80 °C

4.2: 0.08 h / 0 °C

5.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

6.2: 2 h / 50 °C

With dmap; tert.-butylnitrite; hydrogen; potassium carbonate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Suzuki Coupling;