4-[(1R,3R,4R)-4-{[bis(4-fluorophenyl)methyl]carbamoyl}-3-(4-cyanophenyl)cyclohexyl]-morpholine trifluoroacetate

Base Information

Chemical Name:4-[(1R,3R,4R)-4-{[bis(4-fluorophenyl)methyl]carbamoyl}-3-(4-cyanophenyl)cyclohexyl]-morpholine trifluoroacetate
CAS No.:1350711-40-8
Molecular Formula:C₂HF₃O₂*C₃₁H₃₁F₂N₃O₂
Molecular Weight:629.627
Hs Code.:

Synonyms:4-[(1R,3R,4R)-4-{[bis(4-fluorophenyl)methyl]carbamoyl}-3-(4-cyanophenyl)cyclohexyl]-morpholine trifluoroacetate

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Chemical Property of 4-[(1R,3R,4R)-4-{[bis(4-fluorophenyl)methyl]carbamoyl}-3-(4-cyanophenyl)cyclohexyl]-morpholine trifluoroacetate

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Technology Process of 4-[(1R,3R,4R)-4-{[bis(4-fluorophenyl)methyl]carbamoyl}-3-(4-cyanophenyl)cyclohexyl]-morpholine trifluoroacetate

There total 12 articles about 4-[(1R,3R,4R)-4-{[bis(4-fluorophenyl)methyl]carbamoyl}-3-(4-cyanophenyl)cyclohexyl]-morpholine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 773837-37-9
sodium cyanide

: 1350710-24-5
(1R,2R,4R)-N-[bis(4-fluorophenyl)methyl]-2-(4-bromophenyl)-4-(morpholin-4-yl)cyclohexanecarboxamide

: 76-05-1
trifluoroacetic acid

: 1350711-40-8
4-[(1R,3R,4R)-4-{[bis(4-fluorophenyl)methyl]carbamoyl}-3-(4-cyanophenyl)cyclohexyl]-morpholine trifluoroacetate

Guidance literature:: sodium cyanide; (1R,2R,4R)-N-[bis(4-fluorophenyl)methyl]-2-(4-bromophenyl)-4-(morpholin-4-yl)cyclohexanecarboxamide; With 18-crown-6 ether; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 12h; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 1350711-40-8
4-[(1R,3R,4R)-4-{[bis(4-fluorophenyl)methyl]carbamoyl}-3-(4-cyanophenyl)cyclohexyl]-morpholine trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 3.92 h / 20 - 39 °C / Inert atmosphere

1.2: 0 - 20 °C / Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 12 h / 20 °C

3.1: 18-crown-6 ether / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

With 18-crown-6 ether; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide;

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 1350711-40-8
4-[(1R,3R,4R)-4-{[bis(4-fluorophenyl)methyl]carbamoyl}-3-(4-cyanophenyl)cyclohexyl]-morpholine trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 3.92 h / 20 - 39 °C / Inert atmosphere

1.2: 0 - 20 °C / Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 12 h / 20 °C

3.1: 18-crown-6 ether / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

With 18-crown-6 ether; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide;