(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

Base Information

Chemical Name:(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one
CAS No.:956223-40-8
Molecular Formula:C₁₇H₁₉Cl₂F₂NO₂
Molecular Weight:378.246
Hs Code.:

Synonyms:(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

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Chemical Property of (R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

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Technology Process of (R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

There total 7 articles about (R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 956223-39-5
(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

: 956223-40-8
(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

Guidance literature:: With hydrogen; palladium hydroxide on carbon; In ethyl acetate; under 760.051 Torr;

Reference yield:

: 955373-73-6
(R)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

: 956223-40-8
(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / dichloromethane / 1 h / 20 °C

1.2: 4 h / 20 °C

2.1: hydrogen / palladium hydroxide on carbon / ethyl acetate / 760.05 Torr

With hydrogen; acetic acid; palladium hydroxide on carbon; In dichloromethane; ethyl acetate;

Reference yield:

: 955373-72-5
(R)-4-benzyl-3-[(S)-2-(4-benzyloxy-2,6-dichloro-benzyl)-pent-4-enoyl]-oxazolidin-2-onecf

: 956223-40-8
(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: ozone / dichloromethane / 3 h / -74 °C

1.2: -74 - 20 °C

2.1: acetic acid / dichloromethane / 1 h / 20 °C

2.2: 4 h / 20 °C

3.1: hydrogen / palladium hydroxide on carbon / ethyl acetate / 760.05 Torr

With hydrogen; ozone; acetic acid; palladium hydroxide on carbon; In dichloromethane; ethyl acetate;