(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

Base Information

Chemical Name:(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one
CAS No.:956223-39-5
Molecular Formula:C₂₄H₂₅Cl₂F₂NO₂
Molecular Weight:468.371
Hs Code.:

Synonyms:(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

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Chemical Property of (R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

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Technology Process of (R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

There total 4 articles about (R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 675112-70-6
4,4-difluorocyclohexylamine hydrochloride

: 955373-73-6
(R)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

: 956223-39-5
(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

Guidance literature:: 4,4-difluorocyclohexylamine hydrochloride; (R)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde; With acetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 4h;

With water; In dichloromethane;

Reference yield:

: 955373-72-5
(R)-4-benzyl-3-[(S)-2-(4-benzyloxy-2,6-dichloro-benzyl)-pent-4-enoyl]-oxazolidin-2-onecf

: 956223-39-5
(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: ozone / dichloromethane / 3 h / -74 °C

1.2: -74 - 20 °C

2.1: acetic acid / dichloromethane / 1 h / 20 °C

2.2: 4 h / 20 °C

With ozone; acetic acid; In dichloromethane;

Reference yield:

: 94278-70-3
2-(bromomethyl)-1,3-dichloro-5-methoxybenzene

: 956223-39-5
(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -75 - -25 °C

1.2: 1.08 h / -60 - 10 °C

2.1: ozone / dichloromethane / 3 h / -74 °C

2.2: -74 - 20 °C

3.1: acetic acid / dichloromethane / 1 h / 20 °C

3.2: 4 h / 20 °C

With ozone; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;