benzyl 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2-(dimethylaminomethyl)-2,3-dihydrobenzofuran-4-carboxylate

Base Information

Chemical Name:benzyl 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2-(dimethylaminomethyl)-2,3-dihydrobenzofuran-4-carboxylate
CAS No.:1280666-83-2
Molecular Formula:C₃₃H₄₀N₆O₄
Molecular Weight:584.718
Hs Code.:

Synonyms:benzyl 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2-(dimethylaminomethyl)-2,3-dihydrobenzofuran-4-carboxylate

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Chemical Property of benzyl 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2-(dimethylaminomethyl)-2,3-dihydrobenzofuran-4-carboxylate

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Technology Process of benzyl 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2-(dimethylaminomethyl)-2,3-dihydrobenzofuran-4-carboxylate

There total 10 articles about benzyl 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2-(dimethylaminomethyl)-2,3-dihydrobenzofuran-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.2%

: 755039-55-5
(R)-2-chloro-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one

: 1280666-82-1
benzyl 7-amino-2-(dimethylaminomethyl)-2,3-dihydrobenzofuran-4-carboxylate

: 1280666-83-2
benzyl 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2-(dimethylaminomethyl)-2,3-dihydrobenzofuran-4-carboxylate

Guidance literature:: (R)-2-chloro-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one; benzyl 7-amino-2-(dimethylaminomethyl)-2,3-dihydrobenzofuran-4-carboxylate; With toluene-4-sulfonic acid; In Methyl isobutyl carbinol; for 3h; Reflux; Inert atmosphere;

With sodium hydrogencarbonate; In water; at 20 - 30 ℃;

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1280666-83-2
benzyl 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2-(dimethylaminomethyl)-2,3-dihydrobenzofuran-4-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / toluene / 16 h / Reflux; Inert atmosphere

2.1: potassium carbonate / acetonitrile / 3 h / Reflux; Inert atmosphere

3.1: 3.5 h / 190 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / 1,2-dichloro-ethane / 3 h / 70 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 2 h / 20 - 30 °C / Cooling with ice; Inert atmosphere

6.1: triethylamine / acetonitrile / 0.33 h / 20 - 30 °C / Inert atmosphere

6.2: 3 h / Inert atmosphere; Reflux

7.1: acetic acid; iron / 2 h / 20 - 30 °C / Inert atmosphere

7.2: 20 - 30 °C / pH ~ 10

8.1: toluene-4-sulfonic acid / Methyl isobutyl carbinol / 3 h / Reflux; Inert atmosphere

8.2: 20 - 30 °C

With iron; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; toluene-4-sulfonic acid; In Methyl isobutyl carbinol; dichloromethane; 1,2-dichloro-ethane; toluene; acetonitrile;

Reference yield:

: 619-14-7
3-hydroxy-4-nitro-benzoic acid

: 1280666-83-2
benzyl 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2-(dimethylaminomethyl)-2,3-dihydrobenzofuran-4-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / toluene / 16 h / Reflux; Inert atmosphere

2.1: potassium carbonate / acetonitrile / 3 h / Reflux; Inert atmosphere

3.1: 3.5 h / 190 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / 1,2-dichloro-ethane / 3 h / 70 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 2 h / 20 - 30 °C / Cooling with ice; Inert atmosphere

6.1: triethylamine / acetonitrile / 0.33 h / 20 - 30 °C / Inert atmosphere

6.2: 3 h / Inert atmosphere; Reflux

7.1: acetic acid; iron / 2 h / 20 - 30 °C / Inert atmosphere

7.2: 20 - 30 °C / pH ~ 10

8.1: toluene-4-sulfonic acid / Methyl isobutyl carbinol / 3 h / Reflux; Inert atmosphere

8.2: 20 - 30 °C

With iron; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; toluene-4-sulfonic acid; In Methyl isobutyl carbinol; dichloromethane; 1,2-dichloro-ethane; toluene; acetonitrile;