4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid

Base Information

Chemical Name:4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid
CAS No.:13317-11-8
Molecular Formula:C10H8 N2 O3
Molecular Weight:204.185
Hs Code.:
European Community (EC) Number:236-348-7,236-235-2
NSC Number:117329
DSSTox Substance ID:DTXSID60927709
Nikkaji Number:J213.779H,J213.834D
Mol file:13317-11-8.mol

Synonyms:4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid;13250-97-0;13317-11-8;4-Hydroxy-7-methyl-[1,8]naphthyridine-3-carboxylic acid;1,4-Dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid;7-methyl-4-oxo-1H-1,8-naphthyridine-3-carboxylic acid;3-Carboxy-4-hydroxy-7-methyl-1,8-naphthyridine;EINECS 236-235-2;EINECS 236-348-7;7-methyl-4-oxo-8H-1,8-naphthyridine-3-carboxylic acid;NSC117329;Oprea1_217462;SCHEMBL2420837;SCHEMBL8424799;DTXSID60927709;HMS3435A19;7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid;BBL027604;MFCD00006733;STK918860;AKOS000281430;AKOS000301356;CCG-126839;NSC 117329;NSC-117329;VS-08568;4-Hydroxy-7-methyl-1,8-naphthyridine-3-;CS-0248158;FT-0692506;EN300-39270;A806447;J-006184;BRD-K53791146-001-01-8;4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylicacid;4-hydroxy-7-methyl[1,8]naphthyridine-3-carboxylic acid;F3099-7232;Z398556736;1,8-Naphthyridine-3-carboxylic acid, 4-hydroxy-7-methyl-;4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid, 97%;SJN

Suppliers and Price of 4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid

Chemical Property:

Boiling Point:396.2°Cat760mmHg
PKA:-0.43±0.40(Predicted)
Flash Point:193.4°C
PSA：83.05000
Density:1.439g/cm³
LogP:0.92970
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:204.05349212
Heavy Atom Count:15
Complexity:338

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC2=C(C=C1)C(=O)C(=CN2)C(=O)O

Technology Process of 4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid

There total 4 articles about 4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35482-56-5
ethyl 7-methyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

: 13317-11-8
1,4-Dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: With sodium hydroxide;
DOI:10.1021/ja01190a038

Reference yield:

: 1824-81-3
2-Amino-6-methylpyridine

: 13317-11-8
1,4-Dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / xylene / 135 °C

2: 48 percent / diphenyl ether / 230 °C

3: KOH / ethanol

With potassium hydroxide; In diphenylether; ethanol; xylene;
DOI:10.1016/S0960-894X(02)00026-4

Reference yield:

: (Z)-2-(2-Amino-6-methyl-pyridine-3-carbonyl)-3-ethoxy-acrylic acid ethyl ester

: 13317-11-8
1,4-Dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / diphenyl ether / 230 °C

2: KOH / ethanol

With potassium hydroxide; In diphenylether; ethanol;
DOI:10.1016/S0960-894X(02)00026-4