(3S,7R)-9-benzyloxy-6-hydroxy-3-(4-methoxybenzyl)oxy-7-triethylsilyloxy-1-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}nonan-4-one

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Chemical Name:(3S,7R)-9-benzyloxy-6-hydroxy-3-(4-methoxybenzyl)oxy-7-triethylsilyloxy-1-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}nonan-4-one
CAS No.:389086-09-3
Molecular Formula:C₄₄H₇₄O₇S₂Si₂
Molecular Weight:835.37
Hs Code.:

Synonyms:(3S,7R)-9-benzyloxy-6-hydroxy-3-(4-methoxybenzyl)oxy-7-triethylsilyloxy-1-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}nonan-4-one

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Chemical Property of (3S,7R)-9-benzyloxy-6-hydroxy-3-(4-methoxybenzyl)oxy-7-triethylsilyloxy-1-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}nonan-4-one

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Technology Process of (3S,7R)-9-benzyloxy-6-hydroxy-3-(4-methoxybenzyl)oxy-7-triethylsilyloxy-1-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}nonan-4-one

There total 13 articles about (3S,7R)-9-benzyloxy-6-hydroxy-3-(4-methoxybenzyl)oxy-7-triethylsilyloxy-1-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}nonan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 389085-92-1
(R)-4-benzyloxy-2-(triethysilyloxy)butanal

: 389085-91-0
(S)-3-(4-methoxybenzyl)oxy-5-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}-pentan-2-one

: 389086-09-3
(3S,7R)-9-benzyloxy-6-hydroxy-3-(4-methoxybenzyl)oxy-7-triethylsilyloxy-1-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}nonan-4-one

Guidance literature:: (S)-3-(4-methoxybenzyl)oxy-5-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}-pentan-2-one; With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; zinc(II) chloride; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.66667h;

(R)-4-benzyloxy-2-(triethysilyloxy)butanal; In tetrahydrofuran; hexane; at -78 - -50 ℃; for 1.5h;
DOI:10.1016/S0040-4020(02)01379-0

Reference yield:

: 994-30-9
triethylsilyl chloride

: 389086-09-3
(3S,7R)-9-benzyloxy-6-hydroxy-3-(4-methoxybenzyl)oxy-7-triethylsilyloxy-1-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}nonan-4-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 98 percent / imidazole / CH₂Cl₂ / 2 h / 0 - 20 °C

2.1: 87 percent / diisobutylaluminium hydride / CH₂Cl₂; hexane / 2 h / -78 - -20 °C

3.1: 92 percent / pyridine*SO₃; Et₃N / dimethylsulfoxide / 1.25 h / 20 °C

4.1: 92 percent / tetrahydrofuran; diethyl ether / 2 h / -78 - -50 °C

5.1: 93 percent / SO₃*pyridine; Et₃N / dimethylsulfoxide / 1.25 h / 20 °C

6.1: nBuLi; HMDS; ZnCl₂ / hexane; tetrahydrofuran / 1.67 h / -78 - 0 °C

6.2: 98 percent / tetrahydrofuran; hexane / 1.5 h / -78 - -50 °C

With 1H-imidazole; n-butyllithium; pyridine-SO₃ complex; sulfur trioxide pyridine complex; diisobutylaluminium hydride; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; zinc(II) chloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; 3.1: Parikh-Doering oxidation / 5.1: Parikh-Doering oxidation;
DOI:10.1016/S0040-4020(02)01379-0

Reference yield:

: 389086-04-8
(S)-4-[2-(4-hydroxybutyl)-1,3-dithian-2-yl]-butane-1,2-diol

: 389086-09-3
(3S,7R)-9-benzyloxy-6-hydroxy-3-(4-methoxybenzyl)oxy-7-triethylsilyloxy-1-{2-[4-(triethylsilyloxy)butyl]-1,3-dithian-2-yl}nonan-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 75 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 6 h / 20 °C

2.1: 98 percent / imidazole / CH₂Cl₂ / 2 h / 0 - 20 °C

3.1: 87 percent / diisobutylaluminium hydride / CH₂Cl₂; hexane / 2 h / -78 - -20 °C

4.1: 92 percent / pyridine*SO₃; Et₃N / dimethylsulfoxide / 1.25 h / 20 °C

5.1: 92 percent / tetrahydrofuran; diethyl ether / 2 h / -78 - -50 °C

6.1: 93 percent / SO₃*pyridine; Et₃N / dimethylsulfoxide / 1.25 h / 20 °C

7.1: nBuLi; HMDS; ZnCl₂ / hexane; tetrahydrofuran / 1.67 h / -78 - 0 °C

7.2: 98 percent / tetrahydrofuran; hexane / 1.5 h / -78 - -50 °C

With 1H-imidazole; n-butyllithium; pyridine-SO₃ complex; sulfur trioxide pyridine complex; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; zinc(II) chloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; 4.1: Parikh-Doering oxidation / 6.1: Parikh-Doering oxidation;
DOI:10.1016/S0040-4020(02)01379-0