5-methyl-1-((1R,2R,3S)-tetrahydro-3-benzoyloxymethyl-2-fluoro-1-furanyl)-2,4(1H,3H)-pyrimidinedione

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Chemical Name:5-methyl-1-((1R,2R,3S)-tetrahydro-3-benzoyloxymethyl-2-fluoro-1-furanyl)-2,4(1H,3H)-pyrimidinedione
CAS No.:287933-87-3
Molecular Formula:C₁₇H₁₇FN₂O₅
Molecular Weight:348.331
Hs Code.:

Synonyms:5-methyl-1-((1R,2R,3S)-tetrahydro-3-benzoyloxymethyl-2-fluoro-1-furanyl)-2,4(1H,3H)-pyrimidinedione

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Chemical Property of 5-methyl-1-((1R,2R,3S)-tetrahydro-3-benzoyloxymethyl-2-fluoro-1-furanyl)-2,4(1H,3H)-pyrimidinedione

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Technology Process of 5-methyl-1-((1R,2R,3S)-tetrahydro-3-benzoyloxymethyl-2-fluoro-1-furanyl)-2,4(1H,3H)-pyrimidinedione

There total 15 articles about 5-methyl-1-((1R,2R,3S)-tetrahydro-3-benzoyloxymethyl-2-fluoro-1-furanyl)-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 287933-85-1
5-methyl-1-((1R,2S,3S)-tetrahydro-2-hydroxy-3-benzoyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

: benzoic acid 5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydro-furan-3-ylmethyl ester

: 287933-87-3
5-methyl-1-((1R,2R,3S)-tetrahydro-3-benzoyloxymethyl-2-fluoro-1-furanyl)-2,4(1H,3H)-pyrimidinedione

Guidance literature:: With 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; at -30 - 3 ℃; for 19h;
DOI:10.1007/s007060200024

Reference yield:

: 287933-97-5
2,2'-anhydro-5-methyl-1-((1R,2S,3S)-tetrahydro-2-hydroxy-3-(((4-methoxyphenyl)-diphenylmethoxy)-methyl)-1-furanyl)-2,4(1H,3H)-pyrimidinedione

: 287933-87-3
5-methyl-1-((1R,2R,3S)-tetrahydro-3-benzoyloxymethyl-2-fluoro-1-furanyl)-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / aq. NaOH / ethanol / 9 h / 20 °C

2: 100 percent / Amberlyst 15-H / methanol / 12 h / 20 °C

3: 95 percent / CH₂Cl₂; pyridine / 2 h / -40 - -5 °C

4: 45 percent / DAST / CH₂Cl₂ / 19 h / -30 - 3 °C

With sodium hydroxide; Amberlyst 15-H; 4,4'-diaminostilbene-2,2'-disulfonic acid; In pyridine; methanol; ethanol; dichloromethane;
DOI:10.1007/s007060200024

Reference yield:

: 448896-39-7
5-methyl-1-((1R,2S,3S)-tetrahydro-2-hydroxy-3-hydroxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

: 287933-87-3
5-methyl-1-((1R,2R,3S)-tetrahydro-3-benzoyloxymethyl-2-fluoro-1-furanyl)-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / CH₂Cl₂; pyridine / 2 h / -40 - -5 °C

2: 45 percent / DAST / CH₂Cl₂ / 19 h / -30 - 3 °C

With 4,4'-diaminostilbene-2,2'-disulfonic acid; In pyridine; dichloromethane;
DOI:10.1007/s007060200024