7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(2-pyridin-4-ylethoxy)quinazoline

Base Information

Chemical Name:7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(2-pyridin-4-ylethoxy)quinazoline
CAS No.:1311509-46-2
Molecular Formula:C₂₇H₂₈N₄O₂
Molecular Weight:440.545
Hs Code.:

Synonyms:7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(2-pyridin-4-ylethoxy)quinazoline

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Chemical Property of 7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(2-pyridin-4-ylethoxy)quinazoline

Chemical Property:

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Technology Process of 7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(2-pyridin-4-ylethoxy)quinazoline

There total 4 articles about 7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(2-pyridin-4-ylethoxy)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 5344-27-4
4-(2-hydroxyethyl)pyridine

: 1006889-83-3
7-methoxy-4-(3-phenylpiperidin-1-yl)quinazolin-6-ol

: 1311509-46-2
7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(2-pyridin-4-ylethoxy)quinazoline

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm2001508

Reference yield:

: 3973-62-4
3-phenylpiperidine

: 1311509-46-2
7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(2-pyridin-4-ylethoxy)quinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C / Inert atmosphere

2: methanesulfonic acid; L-methionine / 8 h / 120 - 145 °C / Inert atmosphere

3: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

With methanesulfonic acid; L-methionine; di-tert-butyl-diazodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; isopropyl alcohol; 3: Mitsunobu reaction;
DOI:10.1021/jm2001508

Reference yield:

: 874361-18-9
6,7-dimethoxy-4-(3-phenylpiperidin-1-yl)quinazoline

: 1311509-46-2
7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(2-pyridin-4-ylethoxy)quinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: methanesulfonic acid; L-methionine / 8 h / 120 - 145 °C / Inert atmosphere

2: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

With methanesulfonic acid; L-methionine; di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; 2: Mitsunobu reaction;
DOI:10.1021/jm2001508