4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoro-methyl-phenoxy)-butyric acid

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Chemical Name:4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoro-methyl-phenoxy)-butyric acid
CAS No.:1100767-75-6
Molecular Formula:C₂₃H₂₅F₃N₄O₅
Molecular Weight:494.471
Hs Code.:

Synonyms:4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoro-methyl-phenoxy)-butyric acid

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Chemical Property of 4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoro-methyl-phenoxy)-butyric acid

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Technology Process of 4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoro-methyl-phenoxy)-butyric acid

There total 6 articles about 4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoro-methyl-phenoxy)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1100767-78-9
4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester

: 1100767-75-6
4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoro-methyl-phenoxy)-butyric acid

Guidance literature:: 4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester; With sodium hydroxide; water; In methanol; at 20 ℃; for 2h;

With hydrogenchloride; In methanol; water; pH=3;

Reference yield:

: 113117-17-2
ethyl 3-[(4-cyanophenyl)amino]-3-oxopropanoate

: 1100767-75-6
4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoro-methyl-phenoxy)-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; triethylamine / ethanol / 20 h / 20 °C

2.1: ammonium formate / palladium 10% on activated carbon / acetic acid / 5 h / Heating / reflux

2.2: 4 h / 20 °C

3.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: sodium hydroxide; water / methanol / 2 h / 20 °C

4.2: pH 3

With sodium hydroxide; hydroxylamine hydrochloride; water; ammonium formate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; ethanol; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1100767-24-5
N-[4-(N-hydroxycarbamimidoyl)-phenyl]-malonamic acid ethyl ester

: 1100767-75-6
4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoro-methyl-phenoxy)-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium formate / palladium 10% on activated carbon / acetic acid / 5 h / Heating / reflux

1.2: 4 h / 20 °C

2.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: sodium hydroxide; water / methanol / 2 h / 20 °C

3.2: pH 3

With sodium hydroxide; water; ammonium formate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; acetic acid; N,N-dimethyl-formamide;