4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester

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Chemical Name:4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester
CAS No.:1100767-78-9
Molecular Formula:C₂₅H₂₉F₃N₄O₅
Molecular Weight:522.524
Hs Code.:

Synonyms:4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester

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Chemical Property of 4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester

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Technology Process of 4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester

There total 6 articles about 4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1100767-77-8
4-[4-(1-amino-ethyl)-2-trifluoromethyl-phenoxy]-butyric acid ethyl ester

: 1100767-27-8
N-(4-carbamimidoyl-phenyl)-malonamic acid trifluoroacetate

: 1100767-78-9
4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 113117-17-2
ethyl 3-[(4-cyanophenyl)amino]-3-oxopropanoate

: 1100767-78-9
4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; triethylamine / ethanol / 20 h / 20 °C

2.1: ammonium formate / palladium 10% on activated carbon / acetic acid / 5 h / Heating / reflux

2.2: 4 h / 20 °C

3.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With hydroxylamine hydrochloride; ammonium formate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In ethanol; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1100767-24-5
N-[4-(N-hydroxycarbamimidoyl)-phenyl]-malonamic acid ethyl ester

: 1100767-78-9
4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium formate / palladium 10% on activated carbon / acetic acid / 5 h / Heating / reflux

1.2: 4 h / 20 °C

2.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With ammonium formate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In acetic acid; N,N-dimethyl-formamide;