(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-[(S)-2-methyl-1-(2,2,2-trichloro-ethoxycarbonyl)-propoxycarbonyl]-propyl ester

Base Information

Chemical Name:(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-[(S)-2-methyl-1-(2,2,2-trichloro-ethoxycarbonyl)-propoxycarbonyl]-propyl ester
CAS No.:790302-27-1
Molecular Formula:C₂₆H₃₆Cl₃NO₈
Molecular Weight:596.933
Hs Code.:

(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-[(S)-2-methyl-1-(2,2,2-trichloro-ethoxycarbonyl)-propoxycarbonyl]-propyl ester

Synonyms:(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-[(S)-2-methyl-1-(2,2,2-trichloro-ethoxycarbonyl)-propoxycarbonyl]-propyl ester

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Chemical Property of (S)-2-(Benzyloxycarbonyl-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-[(S)-2-methyl-1-(2,2,2-trichloro-ethoxycarbonyl)-propoxycarbonyl]-propyl ester

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Technology Process of (S)-2-(Benzyloxycarbonyl-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-[(S)-2-methyl-1-(2,2,2-trichloro-ethoxycarbonyl)-propoxycarbonyl]-propyl ester

There total 5 articles about (S)-2-(Benzyloxycarbonyl-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-[(S)-2-methyl-1-(2,2,2-trichloro-ethoxycarbonyl)-propoxycarbonyl]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 18668-12-7,18668-13-8,18668-14-9,18671-18-6
2-(N-benzyloxycarbonyl-N-methylamino)-3-methylbutyric acid 1-carboxy-2-methylpropyl ester

: 790302-25-9
(S)-2-hydroxy-3-methylbutyric acid 2,2,2-trichloroethyl ester

: 790302-27-1
(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-[(S)-2-methyl-1-(2,2,2-trichloro-ethoxycarbonyl)-propoxycarbonyl]-propyl ester

Guidance literature:: With dmap; (R)-10-camphorsulfonic acid; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ol048437p

Reference yield:

: 42417-65-2
Z-MeVal-OH

: 790302-27-1
(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-[(S)-2-methyl-1-(2,2,2-trichloro-ethoxycarbonyl)-propoxycarbonyl]-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / DCC; DMAP; (1R)-(-)-10-camphorsulfonic acid / CH₂Cl₂ / 0 - 20 °C

2: TFA / CH₂Cl₂ / 10 h / 0 °C

3: 70 percent / DCC; DMAP; (1R)-(-)-10-camphorsulfonic acid / CH₂Cl₂ / 0 - 20 °C

With dmap; (R)-10-camphorsulfonic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ol048437p

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 790302-27-1
(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-[(S)-2-methyl-1-(2,2,2-trichloro-ethoxycarbonyl)-propoxycarbonyl]-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran / 0 - 20 °C

2: 93 percent / DCC; DMAP; (1R)-(-)-10-camphorsulfonic acid / CH₂Cl₂ / 0 - 20 °C

3: TFA / CH₂Cl₂ / 10 h / 0 °C

4: 70 percent / DCC; DMAP; (1R)-(-)-10-camphorsulfonic acid / CH₂Cl₂ / 0 - 20 °C

With dmap; (R)-10-camphorsulfonic acid; sodium hydride; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol048437p