(S)-benzyl 2-((1S,3R)-3-(((benzyloxy)carbonyl)amino)cyclohexanecarboxamido)-3-phenylpropanoate

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Chemical Name:(S)-benzyl 2-((1S,3R)-3-(((benzyloxy)carbonyl)amino)cyclohexanecarboxamido)-3-phenylpropanoate
CAS No.:1352568-45-6
Molecular Formula:C₃₁H₃₄N₂O₅
Molecular Weight:514.621
Hs Code.:

Synonyms:(S)-benzyl 2-((1S,3R)-3-(((benzyloxy)carbonyl)amino)cyclohexanecarboxamido)-3-phenylpropanoate

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Chemical Property of (S)-benzyl 2-((1S,3R)-3-(((benzyloxy)carbonyl)amino)cyclohexanecarboxamido)-3-phenylpropanoate

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Technology Process of (S)-benzyl 2-((1S,3R)-3-(((benzyloxy)carbonyl)amino)cyclohexanecarboxamido)-3-phenylpropanoate

There total 3 articles about (S)-benzyl 2-((1S,3R)-3-(((benzyloxy)carbonyl)amino)cyclohexanecarboxamido)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 952616-39-6
(1S,3R)-3-(((benzyloxy)carbonyl)amino)cyclohexanecarboxylic acid

: 2462-32-0
L-phenylalanine benzyl ester hydrochloride

: 1352568-45-6
(S)-benzyl 2-((1S,3R)-3-(((benzyloxy)carbonyl)amino)cyclohexanecarboxamido)-3-phenylpropanoate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/ml2002423

Reference yield:

: 16636-51-4,25912-50-9,34583-99-8,38541-66-1,57043-02-4,81131-39-7,81131-40-0,41235-88-5,933445-51-3,933445-54-6
3-aminocyclohexanecarboxylic acid

: 1352568-45-6
(S)-benzyl 2-((1S,3R)-3-(((benzyloxy)carbonyl)amino)cyclohexanecarboxamido)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / 1,4-dioxane; water / 18 h / 0 - 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml2002423

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1352568-45-6
(S)-benzyl 2-((1S,3R)-3-(((benzyloxy)carbonyl)amino)cyclohexanecarboxamido)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / 1,4-dioxane; water / 18 h / 0 - 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml2002423