(S)-2-((1S,3R)-3-aminocyclohexanecarboxamido)-3-phenylpropanoic acid hydrochloride

Base Information

Chemical Name:(S)-2-((1S,3R)-3-aminocyclohexanecarboxamido)-3-phenylpropanoic acid hydrochloride
CAS No.:1352568-46-7
Molecular Formula:C₁₆H₂₂N₂O₃*ClH
Molecular Weight:326.823
Hs Code.:

Synonyms:(S)-2-((1S,3R)-3-aminocyclohexanecarboxamido)-3-phenylpropanoic acid hydrochloride

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Chemical Property of (S)-2-((1S,3R)-3-aminocyclohexanecarboxamido)-3-phenylpropanoic acid hydrochloride

Chemical Property:

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Technology Process of (S)-2-((1S,3R)-3-aminocyclohexanecarboxamido)-3-phenylpropanoic acid hydrochloride

There total 3 articles about (S)-2-((1S,3R)-3-aminocyclohexanecarboxamido)-3-phenylpropanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352568-45-6
(S)-benzyl 2-((1S,3R)-3-(((benzyloxy)carbonyl)amino)cyclohexanecarboxamido)-3-phenylpropanoate

: 1352568-46-7
(S)-2-((1S,3R)-3-aminocyclohexanecarboxamido)-3-phenylpropanoic acid hydrochloride

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 2h; under 2068.65 Torr;
DOI:10.1021/ml2002423

Reference yield:

: 952616-39-6
(1S,3R)-3-(((benzyloxy)carbonyl)amino)cyclohexanecarboxylic acid

: 1352568-46-7
(S)-2-((1S,3R)-3-aminocyclohexanecarboxamido)-3-phenylpropanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C / 2068.65 Torr

With palladium 10% on activated carbon; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ml2002423

Reference yield:

: 16636-51-4,25912-50-9,34583-99-8,38541-66-1,57043-02-4,81131-39-7,81131-40-0,41235-88-5,933445-51-3,933445-54-6
3-aminocyclohexanecarboxylic acid

: 1352568-46-7
(S)-2-((1S,3R)-3-aminocyclohexanecarboxamido)-3-phenylpropanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / 1,4-dioxane; water / 18 h / 0 - 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C / 2068.65 Torr

With palladium 10% on activated carbon; hydrogen; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml2002423