N-benzyloxycarbonyldipropylglycine

Base Information

• Chemical Name: N-benzyloxycarbonyldipropylglycine
• CAS No.: 84047-60-9
• Molecular Formula: C₁₆H₂₃NO₄
• Molecular Weight: 293.363
• Mol file: 84047-60-9.mol

Synonyms:N-benzyloxycarbonyldipropylglycine

Chemical Property of N-benzyloxycarbonyldipropylglycine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyldipropylglycine

There total 2 articles about N-benzyloxycarbonyldipropylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-amino-2-propyl-pentanoic acid; hydrobromide + benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxycarbonyldipropylglycine (84047-60-9)

Guidance literature:

With sodium hydroxide; at 40 ℃; for 4h; pH=11;

DOI:10.1016/j.tet.2004.07.014

Reference yield: 68.0%

2-amino-2-n-propylvaleric acid (2566-31-6) + benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxycarbonyldipropylglycine (84047-60-9)

Guidance literature:

With hydrogenchloride; zinc; In water; acetonitrile;

Reference yield: 62.0%

N-benzyloxycarbonyldipropylglycine (84047-60-9) → (1-carbamoyl-1-propyl-butyl)-carbamic acid benzyl ester (785836-09-1)

Guidance literature:

N-benzyloxycarbonyldipropylglycine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

With ammonium hydroxide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tet.2004.07.014

upstream raw materials:

2-amino-2-n-propylvaleric acid

benzyl chloroformate

Downstream raw materials:

(1-carbamoyl-1-propyl-butyl)-carbamic acid benzyl ester

Boc-Phe-Dpg-NH₂

Refernces

• 1、 Babu, Vommina V. Suresh,Ananda, Kuppanna. "Zinc promoted rapid and efficient synthesis of Fmoc- and Z-α,α-dialkylamino acids under neutral conditions". . p. 70 - 74. Retrieved 2007/10/03.